HBV感染对乳头状甲状腺癌临床病理及分子生物学特征影响  

THE INFLUENCE OF HEPATITIS B VIRUS INFECTION ON CLINICAL FEATURES AND MOLECULAR BIOLOGICAL CHARACTERISTICS IN PAPILLARY THYROID CARCINOMA

作　　者：王昊[1] 卢瑞春[2] 梁军[1] 林岩松[3] 

机构地区：[1]青岛大学医学院附属医院肿瘤科,山东青岛266003 [2]青岛市市立医院 [3]北京协和医院

出　　处：《齐鲁医学杂志》2013年第6期471-473,共3页Medical Journal of Qilu

摘　　要：目的了解乙型肝炎病毒(HBV)感染对乳头状甲状腺癌(PTC)临床病理及分子生物学特征的影响。方法 PTC病人184例,感染HBV者66例(A组),未感染HBV者118例(B组),比较两组多灶、包膜外浸润、颈部淋巴结浸润、远处转移等临床病理特征和BRAFV600E突变率、RET蛋白表达。结果 A组结节性甲状腺肿检出率高于B组,差异有显著性(χ2=5.33,P<0.05);桥本病检出率高于B组,但差异无统计学意义(P>0.05)。两组间肿瘤大小、多发病灶、包膜外浸润、颈部淋巴结浸润、远处转移、BRAFV600E突变率及RAT蛋白表达情况比较,差异无显著性(P>0.05)。结论既往有HBV感染病史的PTC病人有更高的结节性甲状腺肿检出率。Objective To assess the influence of hepatitis B virus （HBV） infection on the clinical features and molecular biological characteristics in papillary thyroid carcinoma （PTC）. Metltods A total of 184 PTC patients （66 with HBV infection （Group A） and 118 without HBV infection （Group B）） were enrolled in this study. A comparison between the two groups was done in terms of the following items： multifocal lesion, extra-capsular invasion, cervical lymph node invasion, distant metastasis, BRAF V600E mutation rate and RET protein expression. Results The detection rate of nodular goiter （X2 = 5.33 ,P〈0.05） and that of Hashimoto＇s disease were higher in groups A than in group B, but the difference was not significant in regard to Hashimoto＇s （P〉0.05）. The differences between the two groups were not significant in terms of the above-mentioned items （P〉0.05）. Con- clusion More nodular goiter can be detected in PTC patients with a history of HBV infection.

关 键 词：乙型肝炎病毒 甲状腺癌 BRAFV600E RET蛋白 

分 类 号：R736.1[医药卫生—肿瘤]