恶性淋巴瘤组织和血清中nm23的表达及其意义  

THE EXPRESSION OF NM23 AND ITS SIGNIFICANCE IN MALIGNANT LYMPHOMA AND SERUM

作　　者：尹相丛[1] 闫丽萍[2] 杨颉[1] 侯方[1] 邵长峰[3] 

机构地区：[1]青岛大学医学院附属医院血液病研究室,山东青岛266003 [2]青岛大学医学院附属医院妇科,山东青岛266003 [3]青岛大学医学院血液病学教研室,山东青岛266003

出　　处：《齐鲁医学杂志》2013年第6期476-478,共3页Medical Journal of Qilu

摘　　要：目的探讨恶性淋巴瘤组织和血清中nm23的表达及其意义。方法采用免疫组化S-P法和双抗体夹心酶联免疫吸附试验分别检测60例淋巴瘤组织和血清中nm23的表达,并分析其与病人临床病理特征的关系。结果淋巴瘤组织及血清中nm23的表达明显高于对照组(χ2=9.49、t=7.21,P<0.01)。nm23的表达水平与病人性别无关(P>0.05),而与病人年龄、淋巴瘤恶性程度、临床分期、有无骨髓浸润、B症状及LDH水平有关(χ2=8.86～15.25,t=3.03～9.48,P<0.01)。结论 nm23表达水平可反映淋巴瘤的恶性程度。Objective To explore the expression of nm23 and its significance in malignant lymphoma and m serum. Methods By applying immunohistochemical and ELISA method, the expression of nm23 in lymphoma tissue and in serum was de- tected, the correlation between the expression and clinicopathological characteristics was analyzed. Results The expression of nm23 in l ymphoma and serum was obviously higher than that in the control group （x^ 2 = 9.49, t = 7.21, P 〈0.01 ）. The expression of nm23 was not associated with the sex of the patient, but correlated with the patient age, the degree of malignancy, clinical stage, with or without bone marrow infiltration, B symptoms and LDH level （x^2 =8.86-15.25;t =3.03-9.48;P〈0.01）. Conclusion The expression level of nm23 can reflect the extent of malignancy of lymphoma.

关 键 词：淋巴瘤 基因 nm23 免疫组织化学 

分 类 号：R730.4[医药卫生—肿瘤]