胞二磷胆碱辅助治疗对帕金森病轻度认知障碍的影响  

Effects of citicoline adjuvant therapy on mild cognitive impairment in Parkinson＇ s disease

作　　者：李振光[1] 于占彩[1] 林荣海[1] 蒋东晓[1] 于永鹏[1] 丛艳斌[1] 

机构地区：[1]山东省威海市文登中心医院潍坊医学院附属文登中心医院,264400

出　　处：《中国实用医刊》2013年第19期11-13,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨胞二磷胆碱辅助治疗对帕金森病（PD）轻度认知功能障碍（PD—MCI）的作用，以及对PD—MCI患者血浆磷脂（PLs）含量的影响。方法收集2006年5月至2011年6月间参与帕金森病协作研究的85例PD患者的人口学资料，完成帕金森病统一评定量表第Ⅲ部分（UPDRS—Ⅲ）及蒙特利尔认知评估量表（MoCA）的评测。根据评测结果将PD—MCI分为治疗组和对照组，前者在基本药物治疗的基础上加用胞磷胆碱钠胶囊100mg，3次／d口服，分别于治疗后12个月和18个月进行MoCA评测及PLs含量测定。血浆PLs测定采用层析技术结合改良的无机磷定量方法。结果85例PD患者中41例（48．2％）存在PD—MCI。治疗后12、18个月，治疗组和对照组MoCA评分比较差异均有统计学意义（P〈0．05，P〈0．01）；治疗后12、18个月治疗组血浆PLs含量较对照组显著降低（P〈0．01）。结论胞二磷胆碱辅助治疗可延缓PD—MCI患者认知功能下降速率，并能降低其血浆PLs含量，具有神经保护作用。Objective To investigate the effect of citicoline adjuvant therapy on mild cognitive impairment in Parkinson＇ s disease （PD） and the influence on plasma phospholipids （PLs） levels. Meth-ods Eighty-five PD patients were recruited and evaluated by Unified Parkinson＇ s Disease Rating collected for the general information. The patients were Scale （UPDRS） m and Montreal Cognitive Assessment （MoCA）. According to MoCA scores, patients with PD-MCI were divided into citicoline treatment group （citicoline 100 mg, tid orally） and control group（ basic L-dopa or dopamine agonist）. Reevaluating cog- nitive function by MoCA and plasma phopholipids levels at posttreatment 12 months and 18 months. Plas-. ma PLs was assayed by measuring its inorganic phosphorus after separation by chromatograph. Results Forty-one cases in 85 PD patients（48.2% ） were combined with PD-MCI. After 12 months and 18 months treatment period, MoCA scores were significantly higher in citicoline treatment group than those in control group（P 〈 0. 05, P 〈 O. O1 respectively）. Plasma PLs levels were treatment group than those in control group（ P 〈 0. 01 ）. Conclusions significantly decreased in citicoline Citicoline is effective on the adju-vant treatment of PD-MCI, and it could delay cognitive rate of decline in patients with PD. Meanwhile, Citicoline could decrease significantly plasma PLs levels in PD-MCI. Citicoline has neuroprotective effects on patients with PD-MCI.

关 键 词：帕金森病 轻度认知障碍 磷脂 胞二磷胆碱 

分 类 号：R742.5[医药卫生—神经病学与精神病学]