改良电痉挛与氯咪帕明治疗首发抑郁症患者的疗效及安全性对照研究  

The Comparison Study of Treating Patients With First-Episode Depression by Means of Modified Electric Convulsive Therapy and Clomipramine

作　　者：田常青[1] 

机构地区：[1]内蒙古精神卫生中心,内蒙古呼和浩特010010

出　　处：《内蒙古医学杂志》2013年第6期650-653,共4页Inner Mongolia Medical Journal

基　　金：内蒙古卫生厅医疗卫生科研计划项目(2009040)

摘　　要：目的:探讨改良电痉挛治疗(MECT)对首发抑郁症治疗的疗效及安全性。方法:将180例首发抑郁症患者随机分为两组,分别为单用氯咪帕明(下称对照组)组和氯咪帕明与电痉挛治疗联合应用组(下称联用组),观察时间为8周。于基线及治疗1、2、4、6、8周末,采用汉密尔顿抑郁量表(HAMD)评定疗效,采用不良反应症状量表(TESS)和心电图评价治疗的安全性。最终纳入分析联用组和对照组各88例。结果:联用组自治疗第1周末、对照组自治疗第4周末,HAMD焦虑/躯体化、认识障碍、阻滞、绝望感四个因子分和总分显著下降,与基线的差异具有统计学意义(P<0.05);自治疗第6周末始两组患者的HAMD全部7个因子分相比无统计学差异。8周观察中未发现二者对心电图有明显影响。结论:改良电痉挛治疗对首发抑郁症的治疗有良好的疗效,而且起效迅速,安全性较好,对记忆功能早期有一定影响,一般在1个月左右恢复。Objective： To discuss therapeutic efficacy and safety of MECT in first- episode depressive pa- tients. Methods：We divided 180 depressive patients into combined treated group and contrasted group randomly , then observing 8 weeks. To evaluate therapeutic efficacy with HANID at baseline and lth , 2th , 4th , 6th, 8th weekend. To evaluate therapeutic safety with TESS and electrocardiogram changes. Ultimately we analyze 88 patients in each group respectively. Result：There are four kinds of factor （HAMD anxiety/somatization, aware- ness barriers, block, hopelessness）score and total score have significant decrease since the first weekend in two groups and since the 4th weekend in contrasted group . There are significant difference contrast with baseline（P 〈 0.05 or P 〈 0.01 ）. There are no significant difference in 7 kinds of factor score of HAMD since 6th weekend in two groups. There are no significant effect to ECG in 8 weeks. Conclusion： In ourinvestigation , MECT shows favorable therapeutic efficacy and rapid exert effect and nicer safety as well as.

关 键 词：改良电痉挛治疗 氯咪帕明 抑郁症 

分 类 号：R749.41[医药卫生—神经病学与精神病学] R454.1[医药卫生—临床医学]