癌症化学预防:过去,现在和未来(英文)  

A Mini-Review of Chemoprevention of Cancer——Past,Present, and Future

作　　者：Michael B. Sporn Karen T. Liby 

机构地区：[1]Department of Pharmacology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755, USA

出　　处：《化学进展》2013年第9期1421-1428,共8页Progress in Chemistry

基　　金：Supported by NIH R01-CA78814,the National Foundation for Cancer Research and the Breast Cancer Research Foundation

摘　　要：本文将对癌症化学预防的发展历史、研究现状及其未来前景作一简要评述,主要包括以下内容:癌症化学预防的科学基础,正在使用的癌症化学预防药物,对新合成药物的需求,以及面临的挑战等。本文尤其强调了联合用药在有效的癌症预防中的重要性。We present a brief review of the history of chemoprevention of cancer, the present status of this field, and its prospects for the future. Topics covered are the scientific basis for chemoprevention of cancer, drugs in current use for chemoprevention of cancer, the need for new synthetic drugs, and the challenges ahead. The importance of the use of combinations of drugs for effective prevention is stressed.

关 键 词：化学预防 癌症 选择性雌激素受体调控剂 rexinoids 三萜 

分 类 号：R730.1[医药卫生—肿瘤]