STAT2基因多态性与湖南地区HCV感染遗传易感性研究  

Study on the Association of STAT2 Gene Polymorphism with Genetic Susceptibility to HCV Infection in Population in Hunan Province,China

作　　者：袁媛[1] 钟待鸣 张钢[1] 黎明[3] 

机构地区：[1]长沙血液中心,湖南长沙410011 [2]湖南省职业病防治院 [3]中南大学基础医学院免疫学教研室

出　　处：《实用预防医学》2013年第9期1045-1048,共4页Practical Preventive Medicine

基　　金：湖南省卫生厅科技基金课题(基金号:132012-137)

摘　　要：目的 研究信号转导和转录活化蛋白2 （signal transducer and activator of transcription factor 2,STAT2）基因单核苷酸多态性（single nucleotide polymorphism,SNP）位点rs2066807与湖南地区HCV易感相关性. 方法 采用多聚酶链式反应-限制性片段长度（polymerase chain reaction-Restriction Fragment Length Polymorphism,PCR-RFLP）对143例健康人群及103例丙型肝炎病毒（Hepatic C virus,HCV）感染人群STAT2的rs2066807位点进行基因分型. 结果 STAT2rs2066807湖南地区正常健康人群中GG型和CG型分别为134例（93.7％）、9例（3.1％）；等位基因G和C分别为277例（96.9％）、9例（6.3％）；HCv感染病人组的GG、CG型分别为96例（93.2％）、7例（6.8％）,等位基因G、C分别为199例（96.6％）、7例（3.4％）.健康对照组与HCV感染病人组rs2066807基因型及等位基因分布相比差异无统计学意义（P＞0.05）；两等位基因患宫颈癌疾病危险因素差异无统计学意义（OR=0.924,95％CI：0.34～2.52）. 结论 STAT2的SNP rs2066807未显示与HCV易感相关.Objective To study the association of the single nucleotide polymorphism （SNP） of signal transducer and acti- vator of transcription factor 2 （STAT2） gene with genetic susceptibility to HCV infection in the population in Hunan province, China. Methods DNA was extracted from the peripheral blood of 143 healthy controls and 103 patients infected with HCV. The allele polymorphism of STAT2 rs2066807 was detected by PCR- restriction fragment length polymorphism （PCR- RFLP）. Results The distributions of STAT2 rs2066807 GO/CG allele in the healthy control and the population infected with HCV were 93.7%/6.3% and 93.2%/6.8% respectively, and the proportions of C/G were 3.1%/96.9% and 3.4%/96.6%, both of which were not significantly different between the two groups （P）, 0.05/. Their risk to HCV infection were not different （OR = 0. 924, 95 % CI ： 0.34 - 2.52）. Conclusions There is no obvious association between STAT2 rs2066807 and HCV infec- tion susceptibility.

关 键 词：HCV 单核苷酸多态性 STAT 易感性 

分 类 号：R512.63[医药卫生—内科学]