E-cadherin、N-cadherin在乳腺癌中表达变化及意义  

Expression and Significance of E-cadherin and N-cadherin in Breast Carcinoma

作　　者：孙建平[1] 李锋[1] 曹玉文[1] 蒋金芳[1] 万国兴[1] 李文琴[1] 

机构地区：[1]石河子大学医学院病理系,石河子832000

出　　处：《石河子大学学报（自然科学版）》2013年第4期473-476,共4页Journal of Shihezi University(Natural Science)

基　　金：国家自然科学基金项目(30760072)

摘　　要：为观察乳腺浸润性导管癌中,EMT相关表型分子E-cadherin、N-cadherin蛋白表达变化,探讨EMT与乳腺癌变、分级相关性。采用收集70例乳腺癌组织和20例癌旁正常组织制作组织芯片,应用免疫组化EnVision法检测E-cadherin、N-cadherin蛋白表达。结果显示,乳腺浸润性导管癌E-cadherin阳性表达明显降低,同时N-cadherin阳性表达明显升高,E-cadherin与N-cadherin表达呈显著相关性(r=0.405,P<0.05);乳腺癌高、中、低分化组织中,E-cadherin阳性表达逐渐升高,同时N-cadherin阳性表达逐渐降低。由此可知,乳腺癌细胞存在EMT,EMT参与乳腺癌变过程,并与乳腺癌恶性程度有相关性。To detect the EMT phenotype molecule E-cadherin and N-cadherin protein expressions in invasive ductal breast carci- noma,and to investigate the correlation between EMT and breast tumor-genesis and histological grade. E-cadherin and N-cadherin protein expressions were determined by immunohistochemistry envision method in 70 cases of breast cancer and 20 cases of cancer adjacent normal tissue microarray. E-cadherin expression was significantly reduced in invasive ductal breast carcinoma,Simultaneously,N-cadherin expression was significantly increased, and a significant correlation was observed between E- cadherin and N-cadherin, （r=0. 405, P^0.05）. Ranging from High, medium to low breast cancer differentiation, E-cadherin positive expression was gradually increased, while N-cadherin expression was gradually decreased. EMT in breast cancer cell was involved in breast tumor-genesis and associated with the malignancy of breast carcinoma.

关 键 词：乳腺癌 EMT E-CADHERIN N-CADHERIN 

分 类 号：R737.9[医药卫生—肿瘤]