初步探讨口腔鳞状细胞癌中的p33/ING1表达的意义  

Discussion of the Significance of the p33/ING1 Gene Expression in Oral Squamous Cell Carcinoma

作　　者：王晓峰[1] 张天夫[1] 王伟[1] 刘新[1] 

机构地区：[1]吉林大学中日联谊医院口腔科,吉林长春130033

出　　处：《中国实验诊断学》2013年第9期1609-1611,共3页Chinese Journal of Laboratory Diagnosis

基　　金：吉林省科技厅资助(201201060);吉林省卫生厅资助(2011Z048)

摘　　要：目的观察口腔鳞状细胞癌中的p33/ING1基因表达情况,探讨其临床意义。方法分别选取口腔黏膜正常组织30例、异常口腔黏膜增生组织30例、口腔鳞状细胞癌黏膜组织30例,观察p33/ING1在人正常口腔黏膜上皮角化细胞(Normal Oral Keratinocyte,NOK)、人口腔黏膜上皮异常增生细胞(Dysplastic Oral Keratinocyte,DOK)和人口腔鳞状细胞癌细胞(Oral Squamous Cell Carcinoma,OSCC)中的表达情况。结果 ING在NOK细胞中的表达要远远高于在OSCC细胞中的表达,有显著性差异和统计学意义(P<0.05)。结论 p33/ING1蛋白的表达在OSCC细胞中的表达显著下降,p33/ING1表达在口腔鳞状细胞癌的发展中具有重要意义。Objective To observe the p33/ING1 gene expression level in oral squamous cell carcinoma（OSCC） and discuss its clinical significance. Methods 30 cases of the normal and 30 cases of increased oral mucosa tissues and 30 cases of OSCC mucosa tissues were selected respectively, then the p33/ING1 gene expressionlevel in normal oral kerati nocyte（NOK）,dysplastic oral keratinocyte（DOK） and oral squamous cell carcinoma（OSCC） cells were observed. Results ING expression level in NOK cell was obviously higher than OSCC cell（p〈0.05）. Conclusion The p33/ING1 protein expression level in OSCC cells is significantly decreased, and p33/ING1 gene has an important significance in OSCC development.

关 键 词：口腔鳞状细胞癌 P33 ING1 基因表达 

分 类 号：R739.8[医药卫生—肿瘤]