棕色脂肪活动状态对肿瘤组织摄取^(18)F-FDG的影响  

Inluence of brown adipose tissue activity on^(18)F-FDG uptake in tumors

作　　者：吴欣[1] 李彪[1,2] 海汪溪[1] 徐宇虹[1,3] 彭金良[1] 

机构地区：[1]上海交通大学生物医学工程学院Med-X-瑞金医院分子影像中心,上海200030 [2]上海交通大学医学院附属瑞金医院核医学科,上海200025 [3]上海交通大学药学院分子药剂学实验室,上海200240

出　　处：《肿瘤》2013年第9期765-769,共5页Tumor

基　　金：国家自然科学基金资助项目(编号:81273465;30801446)

摘　　要：目的:应用正电子发射断层扫描(positron emission tomography,PET)/计算机断层成像(computed tomography,CT)技术研究棕色脂肪组织(brown adipose tissue,BAT)活动情况对荷瘤小鼠肿瘤组织摄取18F-氟-2-脱氧葡萄糖(^(18)F-luoro-2-deoxyglucose,^(18)F-FDG)的影响。方法:建立人肺癌NCI-H1299小鼠移植瘤模型,随后采用人工控制实验条件的方法调节小鼠BAT的活动;实验分为2组:抑制组通过禁食、麻醉和加热处理抑制BAT的活动,激发组则通过食物干预和冷刺激激发BAT的活动。对2组小鼠进行micro-PET/CT成像检测,比较BAT不同活动状态下小鼠肿瘤摄取18F-FDG的情况,并计算标准摄取值(standard uptake value,SUV)。结果:BAT激发组小鼠的肿瘤在PET/CT图像中几乎是不可见的,其摄取18F-FDG的SUV值为0.15±0.06,显著低于BAT抑制组的0.58±0.20(P<0.05)。结论:BAT活动的增加会显著降低肿瘤对^(18)F-FDG的摄取,从而影响肿瘤的成像效果。Objective： To evaluate the influence of BAT （brown adipose tissue） activity on 18F-FDG （18F-fluoro-2-deoxyglucose） uptake in tumors in cancer-bearing mice by using PET/CT （positron emission tomography/computed tomography） imaging. Methods： The model of mice bearing NCI-H1299 human non-small cell lung cancer was established. The activity of BAT in mice was adjusted through regulating the experimental conditions. Two groups were designed in this study, including BAT-activation group （the activity of BAT in mice was stimulated by cold exposure and food diet during the period of 18F-FDG uptake） and BAT-inhibition group （the activity of BAT in mice was inhibited by fasting, anesthesia and heating）. The mice were scanned with micro-PET/CT and the uptake of 18F-FDG in tumors in the two groups was analyzed and compared. The SUV （standard uptake value） was calculated. Results： The tumor in BAT-activation group was nearly invisible on PET image and its 18F-FDG uptake value （SUV 0.15±0.06） was significantly lower than that in the BAT-inhibition group （SUV 0.58±0.20） （P 〈 0.05）. Conclusion： The enhancement of BAT activity will significantly decrease the uptake of 18F-FDG in tumors and influence the imaclincl of the tumors.

关 键 词：癌 非小细胞肺 氧脱氧葡萄糖F18 正电子发射断层显像术 棕色脂肪 

分 类 号：R730.44[医药卫生—肿瘤]