上皮间质转化与循环肿瘤细胞  

Epithelial-mesenchymal transition and circulating tumor cells

作　　者：刘慧颖[1] 殷正丰[1] 

机构地区：[1]第二军医大学东方肝胆外科医院分子肿瘤实验室,上海200438

出　　处：《肿瘤》2013年第9期837-840,共4页Tumor

基　　金：国家科技重大专项基金资助项目(编号:2012ZX10002012-010);国家自然科学基金资助项目(编号:81172207;81272669)

摘　　要：目前认为,上皮间质转化(epithelial-mesenchymal transition,EMT)程序性激活可使肿瘤细胞获得异常的活动能力,从而诱导循环肿瘤细胞(circulating tumor cells,CTCs)产生并存活,经过血液循环传播后,发生间质上皮转化(mesenchymal-epithelial transition,MET),最终形成继发性转移灶。鉴于EMT是诱导CTCs并促进肿瘤转移的一个关键因素,CTCs-EMT在预后诊断和靶向治疗方面正受到越来越多的关注。本文对有关EMT促进CTCs产生和生存,发生EMT的CTCs又通过MET促进CTCs形成肿瘤转移灶的研究进展进行综述,并讨论了检测CTCs-EMT表型的临床应用问题。Currently, it is considered that the tumor cells get abnormal activity by EMT （epithelial- mesenchymal transition） activation, inducing the generation and survival of CTCs （circulating tumor cells）. After dissemination of CTCs through the blood, MET （mesenchymal-epithelial transition） occurs to form secondary tumor metastasis. Given that EMT is a key factor to induce CTCs to promote tumor metastasis, more and more attention was paid on CTCs in prognosis and targeted therapy of tumors. This review is mainly involved the current progress in the role of EMT in generation and survival of CTCs and the role of MET in metastasis formation from EMT-derived CTCs, and discusses the problem of the clinical application of detection of CTCs-EMT phenotype.

关 键 词：肿瘤转移 肿瘤循环细胞 细胞转化 肿瘤 间质细胞 上皮细胞 上皮间质转化 间质上皮转化 

分 类 号：R730.2[医药卫生—肿瘤]