铜绿假单胞菌注射液在恶性胸腔积液治疗中的疗效观察  

Clinical effect of pseudomonas aeruginosa injection on malignant pleural effusion

作　　者：宋飞雪[1] 裴霞霞[1] 金七妹[1] 彭艳[1] 赵军[2] 谢骥[1] 

机构地区：[1]兰州大学第二医院肿瘤内科,兰州市730030 [2]兰州大学第二医院普外一科,兰州市730030

出　　处：《中国肿瘤临床》2013年第18期1127-1129,共3页Chinese Journal of Clinical Oncology

摘　　要：目的:观察胸腔注入铜绿假单胞菌注射液治疗恶性胸腔积液的临床疗效。方法:将90例恶性胸腔积液患者随机分为治疗组31例,对照组A 29例,对照组B 30例。治疗组予以胸腔注入铜绿假单胞菌注射液治疗,对照组A和B分别予以胸腔注入顺铂和白介素-2治疗。比较3组临床疗效及不良反应。结果:治疗组总有效率80.6%,对照组A和对照组B的总有效率分别为51.7%和56.7%,治疗组有效率高于对照组,差异具有统计学意义(P<0.05),同时,治疗组严重不良反应发生率低。结论:胸腔注入铜绿假单胞菌注射液治疗恶性胸腔积液疗效明显,不良反应轻,值得临床推广应用。Objective： To observe the effect of thoracic infusion ofpseudomonas aeruginosa injection in malignant pleural effusion. Methods： A total of 90 patients with malignant pleural effusion were randomly divided into treatment group （31 cases）,control group A （29 cases） and control group B（30 cases）. Treatment group was treated with pseudomonas aeruginosa through intrathoracic infusion. Control group A and B were respectively treated with cisplatin and interleukin-2 through intrathoracic infusion. The clinical efficacy and adverse reaction were compared among the three groups. Results： The total effective rate of treatment group was 80.6%,the total effective rates of the control group A and B were 51.7% and 56.7% respectively.Compared with that of contral groups, the total effective rate of treatment group was higher, and the differences were statistically significant （P〈0.05）. The incidence of serious side effects and toxicity was lower in treatment group than in control groups. Conclusion： The effect of thoracic infusion of pseudomonas aeruginosa injection for malignant pleural effusion is significant, and the adverse reaction is mild. Thus it is worth to be promoted clinically.

关 键 词：铜绿假单胞菌注射液恶性胸腔积液顺铂 白介素-2 

分 类 号：R730.5[医药卫生—肿瘤]