肥胖 脂肪因子与食管腺癌的研究进展  

Research progress on obesity, adipokines, and esophageal adenocarcinoma

作　　者：段晓峰[1] 唐鹏[1] 于振涛[1] 

机构地区：[1]天津医科大学肿瘤医院食管肿瘤科,国家肿瘤临床医学研究中心,天津市肿瘤防治重点实验室,天津市300060

出　　处：《中国肿瘤临床》2013年第18期1134-1136,共3页Chinese Journal of Clinical Oncology

摘　　要：肥胖与肿瘤是全球两大影响健康的重要问题,肥胖增加食管腺癌的发病及死亡风险。脂肪组织能够分泌多种生物学活性的脂肪因子,如瘦素、脂联素、抵抗素等。近年研究发现脂肪因子在胃食管返流病、Barrett食管及癌变中发挥重要作用。本文就肥胖及脂肪因子与食管腺癌的研究进展进行综述。Obesity has rapidly become a pandemic and is associated with increased carcinogenesis, especially esophageal adeno carcinoma （EA）. Adipose tissue is considered an endocrine organ because of its capacity to secrete a variety of adipokines, such as leptin, adiponectin, and resistin. Adipokines have recently been found to be associated with different types of chronic esophageal diseas es, including gastro-esophageal reflux diseases, Barrett esophagus, and carcinogenesis. First-hand evidence supporting the inhibitory and/or active function of adipokines has been collected on human EA. This review aims to provide important insights into the potential mechanisms of adipokines in EA progression.

关 键 词：食管腺癌 脂肪因子 瘦素 脂联素 

分 类 号：R735.1[医药卫生—肿瘤]