茚酮肟醚的合成  

Synthesis And Characterization of(Z)-2,3-dihydroind-en-1-one ON-prop-2-ynyloxyme

作　　者：彭杨[1] 朱必敏[1] 程鹏[1] 曾庆东[1] 余瑜[1] 

机构地区：[1]重庆医科大学药学院,重庆市渝中区医学院路1号400016

出　　处：《光谱实验室》2013年第5期2399-2402,共4页Chinese Journal of Spectroscopy Laboratory

摘　　要：以1-茚酮为原料,经盐酸羟胺缩合得到1-茚酮肟,通过溴丙炔取代等得到产物。重点考察了溴丙炔取代的反应温度、反应时间、催化剂。该方法操作简单、成本低、目标产物收率较高,适合于工业化生产。（Z）-2, 3-dihydroind-en-l-one ON-prop- 2-ynyloxyme was synthesized from 1-indanone and hydroxylamine hydrochloride by condensation, alklation with bromopropyne, The substituted reaction temperature,reaction time and catalyst was investigated. The method is simple, lower cost and a higher yield of the target product,suitable for industrial production.

关 键 词：茚酮肟醚 取代 结构表征 优化 

分 类 号：R914.5[医药卫生—药物化学] O657.61[医药卫生—药学]