GSTM1基因多态性与帕金森病发病风险的Meta分析  

Meta-analysis of association between a common copy number variation of the glutathione S-transferase mu1 GSTM1 gene and Parkinson's disease

作　　者：王斌[1,2] 王腾飞[2] 胡哲义 

机构地区：[1]陕西中医学院药学院药理教研室,陕西咸阳712046 [2]美国田纳西大学健康科学中心药理系,田纳西孟菲斯38105 [3]美国田纳西大学药学院临床药理系,田纳西孟菲斯38105

出　　处：《中风与神经疾病杂志》2013年第8期716-718,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：目的利用meta分析方法评价谷胱甘肽S-转移酶M1(glutathione S-transferase M1,GSTM1)基因多态性与帕金森病发病的相关性。方法检索EMbase和PubMed在线数据库,收集GSTM1基因多态性与帕金森病关系的病例对照研究。结果共纳入16篇病例对照研究,其中包括帕金森患者3296例,对照人群5014例。Meta分析结果显示:GSTM1缺失基因型患者其帕金森病发病风险无显著增高(OR=1.13,95%CI=1.03,1.24)。亚组分析表明,GSTM1缺失基因型与高加索人群(OR=1.16,95%CI=1.04,1.29)和亚洲人群(OR=0.89,95%CI=0.7,1.12)的帕金森病发病风险无相关性。结论 GSTM1缺失基因型与帕金森病发病无显著相关。Objective Meta-analysis method to evaluate whether glutathione S-transferase M1（glutathione S-transferase M1,GSTM1） gene polymorphism and Parkinson＇s disease has correlation.Methods We searched EMbase and PubMed database,collecting GSTM1 polymorphisms and Parkinson＇s disease in this study.Results A total of 16 cases studies,including 3,296 of Parkinson＇s patients and 5,014 cases in the control groups.Meta-analysis showed： GSTM1 deletion genotype of its Parkinson＇s disease risk was not statistically significantly higher（OR = 1.13,95% CI = 1.03,1.24）.Subgroup analysis showed that,GSTM1 null genotype and（OR = 0.89,95% CI = 0.7,1.12） Parkinson＇s disease risk without correlation in caucasian populations（OR = 1.16,95% CI = 1.04,1.29） and Asian populations.Conclusion GSTM1 null genotype and Parkinson＇s disease was no significant correlation.

关 键 词：谷胱甘肽S-转移酶M1 帕金森 META分析 

分 类 号：R742.5[医药卫生—神经病学与精神病学]