急性脑梗死患者血脂水平与脑微出血的关系  

Correlation between lipid levels and cerebral microbleeds in patients with acute cerebral infraction

作　　者：张持[1] 王小强[1] 王国珍[1] 汪国宏[1] 吴竹青[1] 吴君仓[1] 王玉[2] 

机构地区：[1]安徽医科大学附属合肥医院神经内科,安徽合肥230011 [2]安徽医科大学第一附属医院神经内科,安徽合肥230022

出　　处：《中风与神经疾病杂志》2013年第8期724-726,共3页Journal of Apoplexy and Nervous Diseases

基　　金：合肥市重大科技项目[合科(2011)25号]

摘　　要：目的探讨急性脑梗死患者血清脂质水平同脑微出血(CMBs)的相关性。方法选择我院2012年1月～2012年12月连续收治的104例急性脑梗死患者,根据MRI磁敏感加权成像(SWI)上有无CMBs分为两组,CMBs组48例和无CMBs组56例。比较两组患者的一般临床资料及血脂水平,并进一步回归分析血脂水平同CMBs相关性。结果与无CMBs组比较,CMBs组患者总胆固醇(TC)和甘油三脂(TG)明显降低,差异有统计学意义(P<0.01;P<0.05)。多因素Logistic回归分析显示TC为CMBs的独立危险因素。结论 CMBs在急性脑梗死患者中患病率较高,血清TC是CMBs的独立危险因素。Objective To investigate whether there is a correlation between serum lipid levels and cerebral microbleeds,a harbinger of future hemorrhagic stroke.Methods Presence and number of cerebral microbleeds（CMBs） were evaluated using susceptibility-weighted imaging（SWI） in consecutive acute ischemic stroke patients admitted to our hospital from January 2012 to December 2012 were rated prospectively.Patients were divided into two groups according to the presence of CMBs.Multivariate models were generated to determine the contribution of demographic、clinical and serum lipids variables to the frequency of CMBs.Results Of 104 patients,48（46.2%） had CMBs evident on SWI.In univariate analysis with presence of CMBs as the outcomer,total cholesterol,triglycerides were significantly associated with the presence of CMBs（P = 0.00,0.03,respectively）.In multivariate logistic regression analysis,total cholesterol was an independent factor increasing the risk of CMBs（P = 0.02）.Conclusion CMBs are more frequently noted in acute ischemic stroke patients,as well as those with low total cholesterol.

关 键 词：脑微出血 胆固醇 缺血性卒中 危险因素 磁共振成像 

分 类 号：R743.3[医药卫生—神经病学与精神病学]