多发性骨髓瘤患者医院感染的临床特点分析  

Analysis of clinical features of hospital infection in the patients with multiple myeloma

作　　者：吴隼[1] 马栋[1] 杨满[1] 字友梅[1] 黄琰[1] 贺立山[1] 

机构地区：[1]新乡医学院第一附属医院血液科,河南新乡453100

出　　处：《中华医院感染学杂志》2013年第17期4181-4182,4187,共3页Chinese Journal of Nosocomiology

基　　金：河南省教育厅基金项目(2006320039)

摘　　要：目的分析多发性骨髓瘤患者医院感染的临床资料,对其临床特点进行总结,以降低医院感染率。方法选取2003年10月-2011年10月接受诊断和治疗的多发性骨髓瘤患者116例,诊断依据参考《医院感染管理学》,有72例患者使用长春新碱、阿霉素和地塞米松进行化疗为VAD组;另外44例患者使用硼替佐米、爱克兰和地塞米松进行化疗为VMP组,分析两组发生医院感染的临床特点。结果多发性骨髓瘤患者医院感染多发生于呼吸道和消化道,其发生率分别为52.83%和35.85%;≥60岁患者医院感染的发生率为53.85%,<60岁患者为39.06%,差异有统计学意义(P<0.05);VMP组患者医院感染的发生率以及平均感染时间为61.11%及(11.2±2.3)d,均明显短于VAD组的34.09%及(6.0±1.1)d(P<0.05)。结论多发性骨髓瘤患者医院感染多发于呼吸道与消化道,年龄对医院感染的发生率有显著性影响,VMP化疗方案比VAD方案患者医院感染发生率低。OBJECTIVE To analyze the clinical data of hospital infections in the patients with multiple myeloma and to summarize the clinical features. METHODS Totally 116 patients with multiple myeloma in our hospital were selected and observed. The clinical features of hospital infections of the patients were analyzed. RESULTS Hospital infections in the patients with multiple myeloma occurred in the respiratory and digestive tract, and the incidence rates were 52.83% and 35.85%. The incidence of hospital infections of the patients above the age of 60 was obviously higher than that of the below the age of 60 （P〈0.05）. The incidence of hospital infections and the average duration of infections of the VMP group were obviously shorter than those of the VAD group （P〈 0. 05）. CONCLUSION The hospital infections mostly occurr in the respiratory and digestive tract. The age has significant effect on hospital infections. The incidence of hospital infections of the VMP program is lower than that of the VAD program.

关 键 词：多发性骨髓瘤 医院感染 临床特点 

分 类 号：R738.1[医药卫生—肿瘤]