治咳川贝枇杷滴丸的质量控制及其挥发性成分的测定  

Quality Control of Zhike Chuanbeipipa Dropping Pills and Determination of Volatile Components

作　　者：殷玮[1] 齐欣[2] 王佳[2] 侯媛媛[3] 董林毅[4] 

机构地区：[1]白求恩国际和平医院药剂科,河北石家庄050082 [2]天津中新药业集团股份有限公司第六中药厂,天津300401 [3]南开大学药学院,天津300071 [4]天津医科大学药学院,天津300070

出　　处：《中国医药工业杂志》2013年第9期878-882,共5页Chinese Journal of Pharmaceuticals

基　　金：国家自然科学基金面上项目资助项目(81173638);国家自然科学基金青年科学基金资助项目(81001682)

摘　　要：采用超高效液相色谱-光电二极管阵列法检测了治咳川贝枇杷滴丸及其相似处方制剂产品的指纹图谱,再用偏最小二乘法进行聚类分析评价研究。结果显示治咳川贝枇杷滴丸过期样品与市售产品间差异最大。继而采用全二维气相色谱-飞行时间质谱(GC×GC/TOF-MS)对治咳川贝枇杷滴丸中的挥发性成分进行定性定量分析。共确定了其中的74个成分,所鉴定的组分占挥发油色谱总馏出峰面积的90.19%。Based on the fingerprints determined by UPLC-PDA method, the cluster analysis of Zhike Chuanbeipipa dropping pills and the similar products were carried out by partial least squares method. The results showed that there was a maximum difference between the expired and valid batches of Zhike Chuanbeipipa dropping pills. Then the volatile components of the pills were qualitative and quantitative analyzed by GCxGC-TOF-MS. Seventy-four chemical compounds were identified, which were accounted for a 90.19 % proportion of total volatile components.

关 键 词：治咳川贝枇杷滴丸 挥发性成分 质量控制 超高效液相色谱-光电二极管阵列法 偏最小二乘法 全二维气相色谱-飞行时间质谱 

分 类 号：O657[理学—分析化学]