咖啡渣提取物的急性毒性与抗炎作用研究  

Study on Acute Toxicity and Anti-inflammatory Effects of Coffee Residue Extract

作　　者：谭银丰[1] 李洪福[1] 王晓杨[1] 张俊清[1] 廖小平[2] 

机构地区：[1]海南医学院药学院海南省热带药用植物研究开发重点实验室,海口571101 [2]海南医学院,海口571101

出　　处：《世界科学技术-中医药现代化》2013年第4期664-666,共3页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：海南医学院2011年海南省社会发展科技专项(2011SF012):废弃咖啡渣再利用及对老年性痴呆作用研究;负责人:廖小平

摘　　要：目的:初步考察咖啡渣提取物的急性毒性与抗炎作用。方法:采用小鼠最大耐受剂量法观察咖啡渣提取物的急性毒性作用,分别用二甲苯与醋酸诱导小鼠急性炎症模型,连续7天分别灌胃给予咖啡渣提取物1.00,2.00,3.00 g·kg-1(按生药量计)。重量法检测小鼠耳肿胀率,伊文思蓝法检测小鼠腹腔毛细血管通透性,观察咖啡渣对炎症小鼠的抗炎作用。结果:咖啡渣提取物的小鼠最大耐受量为8.60 g·kg-1(按生药量计),咖啡渣提取物3.00 g·kg-1能降低二甲苯导致的小鼠耳肿胀率(P<0.05),抑制醋酸导致的小鼠毛细血管通透性增加(P<0.05)。结论:咖啡渣提取物对小鼠具有一定的抗炎作用。This study was aimed to preliminarily evaluate the acute toxicity and anti-inflammatory effects of coffee residue extract.The test maximum tolerated dose was applied in mice by gavage to observe the acute toxicity of coffee residue extract.Mice acute inflammation model was induced by xylene and glacial acetic acid.The gavage administration of coffee residue extract（1.00,2.00,3.00 g·kg-1,in terms of crude drug） was given 7 days continuously.The ear swelling rate and celiac capillary permeability were measured.The results showed that the ex tract of coffee residue maximum tolerated dose in mice is 8.60 g·kg-1（in terms of crude drug）.The coffee residue extract of 3.00 g·kg-1is able to inhibit ear swelling induced by xylene in mice（P 0.05） and the excessive celiac capillary permeability（P 0.05）.It was concluded that the coffee residue extract have certain anti-inflammation activities.

关 键 词：咖啡渣 急性毒性 抗炎 

分 类 号：R285.5[医药卫生—中药学]