孤独症病残儿童家庭再生育及再发情况随访研究  

Recurrence of autism in families with two children

作　　者：谢立春 段山 钟于林 黄茵 曾序春 

机构地区：[1]深圳市人口和计划生育科学研究所,518048 [2]深圳市卫生和人口计划生育委员会

出　　处：《中国计划生育学杂志》2013年第9期591-594,598,共5页Chinese Journal of Family Planning

基　　金：广东省人口计生委2010年科研立项重点项目(2010103)

摘　　要：目的：对深圳市病残儿鉴定批准生育二胎的孤独症儿童家庭进行追踪随访,了解其再生育及孤独症再发情况,为预防病残儿发生提供科学依据.方法：对1990～2010年病残儿医学鉴定中诊断为孤独症的鉴定对象家庭登记建档,通过信函和电话进行随访,调查了解再生育情况和已生育二孩的发育及健康状况.结果：在病残儿鉴定中儿童孤独症患儿数量逐年增多,已成为目前主要鉴定病种.本次随访率97.16％,有68.42％的家庭生育第二个孩子,其男女性别比1.45.发现孤独症患儿6例、疑似病例6例,阳性率10.00％；男女性别比2.0（8/4）,孤独症再发率男、女性（11.27％、8.16％）间无统计学差异（x2 =0.3104,P=0.577）.结论：孤独症病残儿童家庭再生育第二个孩子的再发风险显著高于正常人群,也高于普通病残儿群体,值得高度关注,建议加强再生育优生指导和相关遗传病筛查等服务.Objective：To explore the recurrence of autism in families with two children to provide the scientific basis for birth defect prevention.Methods：Families of children with autism diagnosed in medical authentication between 1990 and 2010 were followed-up through letters or telephone.The development and health status of the second chilel were evaluated.Results：The incidence of autism was increased year by year in the medical authentication.The follow-up rate was 97.16％,and 68.42％ of families in this survey have their second children.The sex ratio was 1.45.There were 6 children with autism and 6 children were suspicious with autism.The positive rate was 10％,and the sex ratio was 2.0 （8：4）.The recurrent rates of autism were 11.27％ and 8.16％ in boys and girls,respectively （x2 =0.310,P =0.577）.Conclusion：Compared with the normal group and other disabled children,the recurrence rate of autism in the second child is significantly higher in families with autistic children.Genetic screening and consultation need to be promoted in families applying for medical authentication due to autism.

关 键 词：孤独症谱系障碍 再生育 再发风险 病残儿 医学鉴定 

分 类 号：R749.94[医药卫生—神经病学与精神病学]