生物转化法生产琥珀酸进展与展望  

Latest Advances of Microbial Production of Succinate

作　　者：杨建刚[1] 朱年青[1] 陈涛[1] 

机构地区：[1]天津大学化工学院系统生物工程教育部重点实验室,天津300072

出　　处：《化学工业与工程》2013年第5期26-32,共7页Chemical Industry and Engineering

基　　金：国家重点基础研究发展计划(2011CBA00804;2012CB725203);教育部博士点基金(20100032120014)

摘　　要：琥珀酸广泛用于食品、医药和化工等行业,市场前景广阔。生物转化法制备琥珀酸具有价格低廉、环境友好、资源可再生等优点,受到国内外学者的广泛关注。综述了近年来该领域研究的热点方向,着重介绍了大肠杆菌、谷氨酸棒杆菌等作为出发菌株的代谢工程改造及菌种发酵优化等方面的研究进展,展望了今后研究的热点方向。Succinic acid has a huge potential market with wide applications in chemical,food,medicine industry,and so on.Bio-based succinate production has attracted much attention in recent years for many reasons such as low price,low pollution or renewable resources.Focusing on the latest achievements in succinate production,this review systematically summarized the focus of the researchers＇ attentions nowadays,especially for metabolic engineering and fermentation optimization of Escherichia coli and Corynebacterium glutamicum.At last,guidelines for future studies are also proposed.

关 键 词：琥珀酸 大肠杆菌 谷氨酸棒杆菌 代谢工程 系统生物学 

分 类 号：Q815[生物学—生物工程]