KAIl、mtsl在食管鳞状细胞癌中的表达及意义研究  

作　　者：王芳[1] 马营[1] 柳江[1] 

机构地区：[1]新疆自治区人民医院肿瘤科,新疆乌鲁木齐830001

出　　处：《中国农村卫生》2013年第04Z期50-51,共2页

摘　　要：目的研究KAIl、mtsl在食管鳞状细胞癌中的表达及意义。方法应用免疫组化S-P法检测食管鳞状细胞癌患者60例，其中哈萨克族33例，汉族27例，观察KAIl、mtsl的表达与食管鳞状细胞癌发生与浸润、转移的关系。结果1）60例食管鳞状细胞癌组织中，KAIl、mtsl的表达阳性检出率分别为：51．7％（31／60）、31.7％（19／60）；2）KAIl在不同组织学分级和有、无淋巴结转移的食管鳞状细胞癌患者中表达差异有显著性，P〈0．05，提示可作为预后判定的参数；mtsl在不同浸润深度食管鳞状细胞癌组织中表达差异有显著性，P〈0．05，提示可作为肿瘤的分期指标。结论提示KAIl蛋白的低表达与食管癌的病情发展及转移的发生相关，mtsl的失活对食管鳞状细胞癌获得浸润转移的潜能可能起着重要作用。联合检测KAIl、mtsl有助于判断食管鳞状细胞癌的生物学行为及预后。Objective Application immunohistochemical S--P method to investigate the expression ofKAI1, mtsl in human squamous cell carcinoma of esophagus and the relationship between clinical sign and their expression. Methods 60 cases tissues with squamous cell carcinoma of esophagus, Ka zakh national minority 33 examples, in Han Nationality 27 examples were examined forKAI1, mtsl gene by immunohistochemisry. Result 1） In 60 cases tissues wifh squamous ceil carcinoma of esophagus the positive expression rates of KAll, mrs1 respectively is： 51.7% （31/60）, 31.7% （19/60） and 38.3% （23/60）. 2） The expression of KAIlgene was significantly lower in carcinoma tissues with lymphnode metastasis than those in carcinoma tissues without lymphnode metastasis （P〈0.05）. The expression of rots1 in deeper invasive group was significantly higher than those in superficial invasive group （P〈0. 05）. Conclusion Decreased expression of KAI1 proteinmay involve in the occurrence of esophagus carcinoma and the formation of metastasis. There is a closed relationship between mtsl and invasion in squamous cell carcinoma of esophagus. Exomines KAI1 and mtsl jointly is helpful in judges the biology behavior and the prognosis of the esophagus squamose cell cancer.

关 键 词：食管鳞状细胞癌 KAll mtsl 

分 类 号：R361.3[医药卫生—病理学]