多系统萎缩16例临床分析  

Clinical Analysis of 16 Cases with Multiple System Atrophy

作　　者：朱建明[1] 刘想林[1] 高云春[1] 郭桂香[1] 徐平[1] 

机构地区：[1]湖南省常德市第一人民医院,湖南常德415000

出　　处：《中国医学创新》2013年第27期141-143,共3页Medical Innovation of China

摘　　要：目的:探讨多系统萎缩(MSA)的临床特点、影像学特征,以利于早期诊断,减少误诊率。方法:回顾性分析16例MSA患者临床资料。结果:拟诊MSA 11例,可能MSA 5例,其中橄榄桥脑小脑萎缩(MSA-OPCA)9例,纹状体黑质变性(MSA-SND)4例,ShyDrager综合征(MSA-SDS)3例,MRI表现上OPCA患者以小脑、脑桥、延髓萎缩为主,SND主要病变在壳核,SDS个别有小脑萎缩。结论:临床表现和MRI结合可提高MSA的诊断率。[ Abstract ] Objective： To analyze clinical manifestations and neuroimage for early diagnosis of multiple system atrophy （ MSA ） .Method： Clinical materials of 16 MSA cases were retrospectively analyzed.Result： 11 cases were probably diagnosed as MSA, another 5 cases were possible MSA.Among the 16 cases, 9 cases were olivopontocerebellar atrophy （ OPCA ）, 4 cases striatonigral degeneration （ SND ）, and 3 cases were Shy- Drager syndrome （ SDS ） .MRI showed that main lesion of OPCA were in cerebellum, pons, medulla, SND in putamen, and partial SDS in cerebellum. Conclusion： The diagnostic accordance rate of MSA can be elevated with correlation between clinical manifestations and brain MRI.

关 键 词：多系统萎缩 Α-突触核蛋白 MRI 临床分析 

分 类 号：R741[医药卫生—神经病学与精神病学]