外放疗联合食管支架治疗不可手术食管癌患者的Meta分析  

Systematic review of esophageal stents plus radiotherapy in the treatment of patients with inoperable esophageal cancer

作　　者：贺生亮[1] 韩彪[1] 马敏杰[1] 魏宁[1] 杨侃[1] 张瑜[1] 

机构地区：[1]兰州大学第一医院胸外科,730000

出　　处：《肿瘤研究与临床》2013年第9期619-621,624,共4页Cancer Research and Clinic

摘　　要：目的评价食管支架联合外放疗与单纯食管支架治疗晚期食管癌患者的疗效和安全性。方法通过计算机检索中国生物医学文献数据库、中文科技期刊数据库、中国期刊全文数据库、CochraneLibrary、Pubmed和Embase等数据库，检索时间为各数据库建库至2012年12月30日，同时辅助其他检索，收集有关食管支架联合外照射与单纯食管支架治疗中晚期食管癌的随机和半随机对照试验。采用RevMan5．0软件进行统计学分析。结果共收集到7个已发表的随机对照试验，443例患者方法学质量评价均为C级。Meta分析结果显示，与单纯食管支架置入组比较，食管支架联合外放疗可提高中晚期食管癌患者的1年生存率，降低局部复发率；两组的上消化道出血、胸痛、食管反流发生率相似。结论食管支架联合外放疗可增加中晚期食管癌患者1年生存率，并降低局部复发率。Objective To evaluate the efficiency and safety of esophageal stents combined with radiotherapy compared with esophageal stents alone in the treatment of advanced esophageal cancer. Methods CBM, VIP, CNKI, Cochrane Library, Pubmed and Embase etc were searched by computer begining from the establishment of these datebases to December 2012. The related references as well as communicated with other researchers were also traced to obtain certain informations. Randomized and quasi-randomized controlled trials compared esophageal stents plus radiotherapy with esophageal stents alone in the treatment of advanced esophageal cancer were included. The statistical software RevMan 5.0 was used. Results Seven published articals were included （443 patients）, and all trails methodological quality were grade C. The results of Meta- analysis showed that compared with esophageal stents along, esophageal stents combined with radiotherapy improve l-year survival rates and reduce the local recurrence rates.Gastrointestinal bleeding rates, chest pain rates, gastro-esophageal reflux rates remained similarily. Conclusion Compared with esophageal stents along, esophageal stents combined with radiotherapy can improve 1-year survival rates and reduce the local recnrrence rates.

关 键 词：食管肿瘤 食管支架 放疗 系统评价 

分 类 号：R735.1[医药卫生—肿瘤]