雌激素受体α基因PvuⅡrs2234693多态性与乳癌发病风险的meta分析  

PvuⅡrs2234693 polymorphisms in estrogen receptor α and breast cancer risk:a meta-analysis

作　　者：杨君霞[1] 郭磊磊[1] 武珍珍[1] 吕恭进[1] 秦洁洁[1] 宋春花[1,2] 

机构地区：[1]郑州大学公共卫生学院流行病学教研室,郑州450001 [2]河南省肿瘤流行病学重点实验室,郑州450001

出　　处：《郑州大学学报（医学版）》2013年第5期588-591,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：国家自然科学基金资助项目81202278

摘　　要：目的：探讨雌激素受体（ ER）α基因PvuⅡrs2234693位点多态性与乳癌发病风险之间的关系。方法：将2002年至2012年国内外发表的ERα基因PvuⅡrs2234693多态性与乳癌关系相关的文献进行检索，并进行异质性检验，计算OR值（95％CI）。结果：符合纳入标准的共有14篇文献，累计乳癌病例10755例，对照17074例。与野生纯合基因型TT相比，CC突变基因型异质性检验P＝0．03，OR（95％CI）为0．91（0．81～1．02）；CT杂合型及CC＋CT联合型的异质性检验P分别为0．57、0．44，OR（95％CI）分别为0．96（0．90～1．02）、0．94（0．89～1．00）。结论：未发现ERα基因PvuⅡrs2234693位点多态性与乳癌发病风险之间的相关性。Aim：To explore the relationship between PvuⅡrs2234693 polymorphisms in estrogen receptor α（ ERα） and risk of breast cancer occurrence .Methods： All literatures related to PvuⅡrs2234693 polymorphisms in ERαand breast cancer which published openly between 2002 and 2012 were reviewed .Heterogeneity test for each research data was performed and OR（95%CI） was analyzed.Results：There were 14 literatures conformed to the inclusion criteria .A total of 10 755 breast cancer cases and 17 074 controls were included .The meta-analysis showed that compared with the wild-type homozygous TT, the P of heterogeneity test for CC variant genotype was 0.03, and OR（95%CI） was 0.91（0.81-1.02）.The P of heterogeneity test for CT heterozygous and CC ＋CT joint type was 0.57, 0.44, and OR（95%CI） was 0.96（0.90-1.02）, 0.94（0.89-1.00）.Conclusion： No relationship between the genotype of PvuⅡrs2234693 poly-morphisms in ERαand risk of breast cancer occurrence is found .

关 键 词：雌激素受体Α 多态性 乳癌 META分析 

分 类 号：R737.9[医药卫生—肿瘤]