HSP70和CRP评估后腹腔镜手术对机体应激功能的影响  

Effect of HSP70and CRP on stress function in retroperitoneoscopic surgery

作　　者：宋旭[1] 周磐石[1] 张圣熙[1] 龚敏[1] 王蓉[1] 林文耀[1] 张耘[1] 黄锦阳[1] 

机构地区：[1]上海市第七人民医院泌尿外科,上海200137

出　　处：《临床泌尿外科杂志》2013年第10期739-741,共3页Journal of Clinical Urology

基　　金：上海市浦东新区卫生局科研基金资助项目(编号PWRD2007-07)

摘　　要：目的:评估后腹腔镜输尿管切开取石术对机体应激功能的影响。方法:50例输尿管切开取石术患者随机分为后腹腔镜组(25例)和传统开放手术组(25例),患者术前、手术开始后2小时、术后24小时、术后48小时抽取静脉血5ml,应用ELISA法定量测定人血浆中热休克蛋白(HSP)70和C反应蛋白(CRP)含量。结果:术前两组患者HSP 70及CRP比较差异无统计学意义(P>0.05)。手术开始后2小时,HSP70与本组术前及组间比较无统计学意义(P>0.05),两组CRP均较术前明显升高,且开放手术组高于后腹腔镜组(P<0.05)。术后24小时,两组HSP70均较术前明显升高,且开放手术组高于后腹腔镜组(P<0.05)。术后48小时,HSP70开始下降,与术前比较差异无统计学意义(P>0.05)。术后24小时及48小时,两组CRP均较术前明显升高,且开放手术组高于后腹腔镜组(P<0.05)。结论:后腹腔镜输尿管切开取石术与开放手术比较,其对机体应激功能影响较小,体现了微创优势。Objective： To evaluate the impact on stress function in retroperitoneoscopic ureterolithotomy. Method： Fifty patients by ureterolithotomy were randomly divided into retroperitoneoscopic group （25 eases） and traditional open surgery group （25 cases）. Five ml of blood from vein were withdrawn preoperatively, two hours after the surgery, 24 hours and 48 hours postoperatively respectively, and were quantitative determined the con- tent of heat shock protein （HSP） 70 and （;-reactive protein （CRP） in human plasma by ELISA. Result： Preopera- tive HSPT0 and CRP in both groups of patients showed no significant difference （P~〉0.05）. The comparison of HSPT0 in the same group preoperatively and two hours postoperatively showed no significant difference （P 0.05）. Moreover, there was no significant difference between two groups. CRP of both groups were significantly higher than preoperative. CRP of open surgery group was higher than retroperitoneoscopic group （P〈~0.05）. HSPT0 of both groups were significantly higher than preoperative 24 hours postoperatively, which HSPT0 of open surgery group was higher than retroperitoneoscopic group （P^0.05）. HSPT0 began to decline 48 hours postoper- atively, which showed no significant difference compared with preoperative （P）0.05）. CRP of both groups was significantly higher than preoperative 24 hours and 48 hours postoperatively and CRP of open surgery group was higher than retroperitoneoscopic group （P%0.05）. Conclusion： Retroperitoneoscopic ureterolithotomy shows the less influence on stress function and reflects the minimally invasive advantages compared with open surgery.

关 键 词：后腹腔镜手术 应激功能 

分 类 号：R572[医药卫生—消化系统]