复方中药安君宁治疗海洛因依赖稽延性戒断症状临床研究  

A controlled study of anjunning for the treatment of protracted withdrwal symptoms

作　　者：王卓[1] 

机构地区：[1]四川大学华西医院

出　　处：《中国药物滥用防治杂志》2013年第5期251-255,共5页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：国家科技部十一五支撑计划课题资助项目;课题编号:2008BAI49B02

摘　　要：目的:评价中药安君宁治疗海洛因依赖稽延性戒断症状(PWS)的疗效及安全性。方法:纳入符合诊断标准的海洛因依赖患者,随机分为安君宁治疗组和安慰剂对照组。采用随机双盲临床研究方法,进行6个月的随访治疗比较,观察指标为稽延性戒断症状评定量表(PWS)、汉密尔顿焦虑量表(HAMA)等。结果:PWS量表提示与安慰剂比较,安君宁在访视3(第4周),稽延性戒断症状量表睡眠因子分差异存在统计学意义(p<0.05)。汉密尔顿焦虑量表提示与安慰剂比较,安君宁在访视前后,汉密尔顿焦虑评分差异不存在统计学意义(P>0.05)。结论:在治疗海洛因依赖稽延性戒断症状时,中药安君宁可以有效缓解巩固期睡眠障碍。Objective： To evaluate the curative effect of adverse reaction of Anjunning in treatment of protracted withdrawal symp- toms（PWS） of herion dependence. Methods： The herion addicts meeting ICD-10 were randomized to Anjunning group and placebo group with double blinding. It was 6 months in treatment. The Scale of PWS and HAMA were used to assess the curative effect. Results ： Comparing that of placebo group, sleep disorder score of PWS score of Anjunning group was remarkable different during the 3^rd interviews （p 〈 0. 05）. HAMA score of Anjunning group was not different with that of placebo group during the interviews. Conclusion： Anjunning is firstly effective in treatment of sleep disorder of PWS.

关 键 词：安君宁 稽延性戒断症状 

分 类 号：R749.6[医药卫生—神经病学与精神病学]