慢性酒精中毒性脑病P300研究  

A study in Chronic Alcoholism Encephalopathy P300

作　　者：许红莉[1] 王培芳[1] 

机构地区：[1]孝感市康复医院药物依赖治疗中心,孝感432000

出　　处：《中国药物滥用防治杂志》2013年第5期266-267,278,共3页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的：研究慢性酒精中毒性脑病（CAE）的P300潜伏期变化特点，探讨P300事件相关电位检测方法对该病的临床应用价值。方法：收集2010年10月-2013年2月间医院药物依赖治疗中心收治的25例CAE患者的临床资料，所有病例在入院初期均进行规范P300事件相关电位检测，重点对病例潜伏期数据进行统计学分析。结果：25例CAE患者P300潜伏期与正常实验室数据比较均有显著延长（P〈0．05）。结论：CAE患者中枢神经系统认知功能的损害是肯定的，P300检测可明确CAE患者脑认知功能损害程度，可为该病的临床诊疗及预后评估提供科学依据。Objective：To study the change characteristics of P300 of Chronic Alcoholism Encephalopathy（CAE） during incubation period, and discuss the clinical application of P300 event-related potential detection method. Methods： 25 clinical data of CAE pa- tients in our Drug Dependence Treatment Center during October 2010-February 2013 have been collected, all cases are p300 event-re- lated potential detected during early period of hospitalization, focus on statistical analysis of the case data during incubation period. Results ： Compared with normal experimental data, the P300 incubation period of all those 25 CAE patients of each age group have sig- nificant extension （P 〈 0.05 ）. Conclusion： The damage in central nervous system and cognitive function of CAE patients is definite, P300 event-related potential detection can specifying the extent of damage in central nervous system and cognitive function of CAE patients, and provide a scientific basis for the clinical diagnosis and treatment and prognosis evaluation of CAE.

关 键 词：酒精中毒 脑病 事件相关电位P300 潜伏期 

分 类 号：R747.9[医药卫生—神经病学与精神病学]