他汀类药物对脑梗死合并HBV感染患者肝功能的影响  

Effects of statins on liver function in cerebral infarction patients of HBV carriers

作　　者：鲍健[1] 张炳俊[1] 林银谣[1] 陆正齐[1] 

机构地区：[1]中山大学附属第三医院神经病学科,广州510630

出　　处：《新医学》2013年第9期607-609,共3页Journal of New Medicine

基　　金：国家自然科学基金项目(81271328);广州市科技计划重大专项(2011Y200017)

摘　　要：目的观察他汀类药物对脑梗死合并HBV携带者的肝功能的影响。方法将248例脑梗死患者按有无HBV感染分为脑梗死组(160例)及HBV组(88例),所有患者均使用他汀类药物治疗,对两组患者用药前、发病后1、3个月的血脂及肝功能进行比较分析。结果入院时两组患者的性别、年龄、美国国立卫生院神经功能缺损评分(NIHSS)、血脂、转氨酶比较差异无统计学意义(P>0.05)。经过1、3个月的治疗,两组的血脂、ALT、AST、谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)、直接胆红素(D-Bil)比较差异仍无统计学意义(P>0.05)。结论他汀类药物不会引起合并HBV感染的脑梗死患者的明显肝损害。Objective To investigate the effects of statins on liver function in cerebral infarction patients of Hepatitis B virus （HBV） carriers. Methods Data of patients （ cerebral infarction patients： 160, cerebral infarction patients of HBV carriers ： 88） treated with statins were recorded. Serum lipid and liver function were evaluated at admission, one month and three months follow-up. Results There was not statistical differ- ence in sex ratio, age, National institutes of health stroke scale （NIHSS） , low-density lipoprotein cholesterol, aminotransferase between two groups at admission （P 〉 0. 05 ）. After one month and three months follow-up, there was not statistical difference in low-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, glutamyl transpeptidase, alkaline phosphatase, direct bilirubin between two groups （P 〉 0. 05 ）. Conclusion Statins should not cause the serious liver injury in cerebral infarction patients of HBV carriers.

关 键 词：他汀类药物 脑梗死 HBV 肝功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R512.62[医药卫生—临床医学]