浓缩鱼肝油加制霉菌素治疗儿童复发性口腔溃疡的临床研究  

Clinical research of concentrated cod-liver oil drops and nystatin treating children recurrent oral ulcer

作　　者：李志雄[1] 李志珍[1] 古桂芳[1] 

机构地区：[1]广东省五华县人民医院,梅州514400

出　　处：《新医学》2013年第9期646-647,共2页Journal of New Medicine

摘　　要：目的比较浓缩鱼肝油加制霉菌素与传统的浓缩鱼肝油加维生素C治疗儿童复发性口腔溃疡的疗效。方法选择儿童复发性口腔溃疡80例,分为观察组和对照组,每组各40例。观察组采用浓缩鱼肝油加制霉菌素治疗,对照组采用浓缩鱼肝油加维生素C治疗,比较两组患儿的疼痛消失时间、近期总有效率及复发率。结果观察组疼痛消失时间为(3.7±1.2)d,对照组为(6.0±2.3)d,两组比较差异有统计学意义(P<0.01)。观察组的总有效率为95%、复发率为5%,对照组相应为78%、38%,观察组总有效率较高(P<0.05),复发率较低(P<0.001)。治疗过程中,两组患儿均无出现明显不良反应。结论浓缩鱼肝油加制霉菌素治疗儿童复发性口腔溃疡可缩短患儿疼痛时间,临床疗效优于传统浓缩鱼肝油加维生素C。Objective To compare the effects between concentrated cod-liver oil with nystatin and concentrated cod-liver oil plus vitamin C for children with recurrent oral ulcer. Methods A total of 80 children with recurrent oral ulcer were selected and divided into two groups, that was observation group and control group, each group for 40 cases. Concentrated cod-liver oil and nystatin were applied in observation group, and then concentrated cod-liver oil and vitamin C applied in control group. The periods of pain disappeared, total effective rates and recurrence rates in two group were compared. Results In observation group, the period of pain disappeared was （3.7 ± 1.2） d, and in control group that was （6. 0 ± 2. 3 ）. The difference was statistically significant （ P 〈 0. 01 ）. The total effective rate and recurrence rate in observation group were 95% , 5%, and those in control were 78% , 38% , respectively. Compared with control group, the total effective rate in observation group was higher （P 〈0. 05） , and recurrence rate was lower （P 〈0. 001 ）. There was no adverse recation in two groups through treatment. Conclusions Concentrated cod-liver oil drops and nystatin for children with oral ulcer, could reduce the periods of pain lasted, which is more effective than concentrated cod- liver oil plus vitamin C.

关 键 词：儿童复发性口腔溃疡 浓缩鱼肝油 制霉菌素 

分 类 号：R781.5[医药卫生—口腔医学]