宫颈高度上皮内瘤变LEEP术后高危型HPV转归的分析  

Analysis of Prognosis of High-risk HPV in High-grade Cervical Intraepithelial Neoplasia Patients Treated with LEEP

作　　者：陆萍[1] 焦桢[1] 隋霜[1] 王琳[1] 

机构地区：[1]新疆自治区人民医院妇科,830001

出　　处：《实用癌症杂志》2013年第5期556-558,共3页The Practical Journal of Cancer

摘　　要：目的探讨宫颈高度鳞状上皮内瘤变行高频电刀环切(LEEP)术后高危型人乳头瘤病毒(HPV)的状态和影响因素。方法对经宫颈活检诊断为CINⅡ或CINⅢ级、高危HPV检测为阳性的138例患者中的108例进行2年的随访,每3～6个月复查高危型HPV、TCT、白带、支原体、衣原体,必要时行阴道镜检查,对术后高危型HPV转归的影响因素进行分析。结果 LEEP术后高危型HPV转阴率为89.8%,转阴平均时间为5.98天。切缘残留病变患者术后HPV转阴率为47.3%,无残留病变者为97.7%,沙眼衣原体感染者术后HPV平均阴转时间为11.9个月,绝经患者平均转阴时间为13.7个月。结论高度上皮内瘤变LEEP术后高危型HPV的转归与患者的切缘状态、衣原体感染、绝经与否有关,与术前HPV载量高低、年龄、支原体感染、阴道炎无关。Objective To investigate the postoperative status and influence factors of high-risk human papillomavirus （HPV） in patients with cervical high-grade squamous intraepithelial neoplasia who received loop electrosurgical excision proce- dure （LEEP）. Methods In the 138 patients, 108 patients diagnosed by cervical biopsy as CIN II or CIN III with positive high- risk HPV received 2 years follow-up, high-risk HPV,TCT,leucorrhea, mycoplasma, chlamydia were checked every 3 - 6 months, colposcopy was performed if necessary,influence factors of prognosis of high risk HPV were analysed. Results Negative rate of high-risk HPV after LEEP was 89.8% , the average time was 5.98 days. Negative rates of HPV in patients with and without mar- gin residual lesions after surgery were 47.3% and 97.7% , respectively, average transition time of HPV in Chlamydia trachomatis infection patients was 11.9 months, average transition time of HPV in menopausal patients was 13.7 months. Conclusion Out- come of HPV in CIN patients who received LEEP is related to margin status, choamydiae infection, menopause, and it is not relat- ed to preoperative HPV load level, age, mycoplasma infection and vaginitis.

关 键 词：宫颈高度上皮内瘤变 人乳头瘤病毒 高频电刀环切术 

分 类 号：R737.33[医药卫生—肿瘤]