肿瘤免疫逃逸机制的研究进展  

Research progress on the mechanism of tumor immune escape

作　　者：阎永贞[1] 那可[1] 魏晓东[1] 金媛媛[1] 赵波[1] 赵文杰[1] 

机构地区：[1]中国医药工业研究总院 上海医药工业研究院创新药物与制药工艺国家重点实验室,上海200040

出　　处：《复旦学报（医学版）》2013年第5期619-624,共6页Fudan University Journal of Medical Sciences

基　　金：国家“重大新药创制”科技重大专项“微生物药物技术创新与新药创制产学研联盟”(2010ZX09401-403)~~

摘　　要：机体中偶然出现的肿瘤细胞可被免疫细胞所识别,并作为异物而加以清除,但肿瘤在机体的免疫监视下仍能产生、发展和转移,表明肿瘤具有免疫逃逸的能力。本文综述了肿瘤免疫过程中肿瘤抗原表达、识别、加工、递呈、T细胞增殖、活化和分化以及免疫效应的产生等一系列环节中肿瘤免疫逃逸机制的研究进展。Tumor cells generated occasionally in the body can be identified and removed as a foreign body by immune cells.The generation,development and metastasis of tumor cells although under the body＆prime;s immune surveillance,suggest that the tumor cells have the capability of immune escape.In this paper,the research progress of tumor immune escape in the process of tumor immunity including tumor antigen expression,identification,processing,presenting,T cell proliferation,activation and differentiation,as well as the emergence of immune effect is reviewed.

关 键 词：肿瘤细胞 树突状细胞 免疫抑制因子 免疫逃逸 

分 类 号：R730.3[医药卫生—肿瘤]