梗阻性黄疸肠黏膜屏障损伤病理生理机制的研究进展  

Pathogenesis of intestinal barrier dysfunction in obstructive jaundice

作　　者：王娜[1,2] 姜慧卿[1,2] 

机构地区：[1]河北医科大学第二医院消化科 [2]河北省消化病研究所,河北省消化病重点实验室,河北省石家庄市050000

出　　处：《世界华人消化杂志》2013年第26期2668-2673,共6页World Chinese Journal of Digestology

摘　　要：肠黏膜屏障具有机械屏障、化学屏障、生物屏障、免疫屏障等功能,是防止肠道内的有害物质和病原体进入机体内环境,维持内环境稳定的一道重要屏障.梗阻性黄疸(obstructive jaundice,OJ)患者病死率和并发症发生率居高不下,主要原因是败血症和肾功能衰竭.临床与基础研究证实OJ存在肠黏膜屏障损伤,其主要病理生理机制是肠黏膜通透性增加、肠黏膜上皮氧化应激损伤及肠源性内毒素血症,具体机制尚未明确.本文对OJ引起的肠黏膜屏障损伤的病理生理机制作一综述.Intestinal mucosal barrier is a key structure that normally prevents the passage of harmful molecules across the mucosa and into the circulation, including mechanical barrier, immunological barrier, biological barrier and chemical barrier. Obstructive jaundice （OJ） is frequently associated with infectious complications, mainly due to sepsis and renal dysfunction. The key events in the pathophysiology of these complications are endotoxemia of gut origin and increased intestinal permeability because of intestinal barrier dysfunction, as demonstrated in experimental and clinical studies. However, the mechanisms involved in this phenomenon remain obscure. Here we review recent progress in understanding the pathogenesis of intestinal barrier dysfunction in OJ.

关 键 词：梗阻性黄疸 肠黏膜屏障 内毒素血症 紧密连接 

分 类 号：R575[医药卫生—消化系统]