肺癌患者急性放射性肺损伤发生的相关因素分析  

Analysis of Factors Associated with the Occurrence of Lung Cancer Patients with Acute Radiation Lung Injury

作　　者：郭本成[1] 

机构地区：[1]山东省莱芜市人民医院肿瘤科,山东莱芜271100

出　　处：《中国医药指南》2013年第26期33-34,共2页Guide of China Medicine

摘　　要：目的探究肺癌患者急性放射性肺损伤发生的相关影响因素。方法将我院2009年至2012年收治的200例行放射治疗的肺癌病患作为研究对象,对他们的性别、年龄、是否化疗、放疗的剂量、V5、V20及平均剂量(MLD)等因素和病患三级及以上急性放射性肺损伤发生率之间的关系进行分析。结果本研究200例放射治疗的肺癌病患,发生三级及以上急性放射性肺损伤的病患为93例(46.50%),对相关因素进行分析后发现以下因素可导致病患发生三级及以上急性放射性肺损伤:吸烟、放疗前化疗周期数较多、同期放化疗、V5>40%、V20>25%(28%)、MLD>10Gy(13Gy)。结论在进行肺癌放疗计划设计时,应根据我国肺癌病患的特点,设定适宜的物理参数;还应对病患的吸烟史、化疗史等因素进行分析,尽量减少急性放射性肺损伤的发生率。Objective TO explore the influence factors related to the occurrence of acute radiation lung injury in patients with lung cancer. Methods Our hospital in the years 2009 to 2012 in 200 consecutive patients who underwent radiotherapy for lung cancer patients as the research object, to their gender, age, chemotherapy, radiotherapy dose, V5, V20 and mean dose （MLD） and the factors such as patient three or more acute radiation lung injury incidence and relation between analysis, Results In this study, 200 cases of radiation therapy for lung cancer patients, grade three and above acute radiation lung injury patients for 93 cases （46.50%）, to analyze the related factors and found the following factors can cause disease incidence of grade three and above acute radiation lung injury： smoking, radiotherapy before the chemotherapy cycle number, chemotherapy, V5〉40%, V20〉25% （28%）, MLD〉10Gy （13Gy）. Conclusion The lung cancer radiotherapy plan, should according to the characteristics of Chinese lung cancer patients, setting parameters suitable; factors to smoking history, disease history of chemotherapy, to reduce the incidence of acute radiation lung injury.

关 键 词：肺癌 急性放射性肺损伤 放疗 相关因素 

分 类 号：R734.2[医药卫生—肿瘤]