RNAi在大肠癌基因治疗中的研究现状  

Study Progress of RNA Interference in the Treatment of Colorectal Cancer Gene

作　　者：陶亮[1] 茆家定[1] 吴佩[1] 

机构地区：[1]芜湖市皖南医学院弋矶山医院胃肠二科,安徽芜湖241000

出　　处：《辽宁医学院学报》2013年第5期91-93,共3页Journal of Liaoning Medical University (LNMU) Bimonthly

基　　金：安徽省自然科学基金资助项目;项目编号:11040606M182;安徽省教育厅自然科学基金资助项目;项目编号:KJ2010B242

摘　　要：RNA干扰(RNA interference)即转录后基因沉默,是由外源或内源性的双链RNA(double standed RNA)导入细胞而引起同源的mRNA降解,进而抑制其相应的基因表达。作为一项新技术,目前广泛地应用于生物体基因功能研究和多种肿瘤的研究。现针对大肠癌有关基因诊疗进行了积极的探索,并取得了突破性的进展。RNA interference （RNAi）, called post -transcriptional gene silencing, is the homologous degradation of mRNA caused by exogenous or endogenous double stranded RNA （dsRNA） , which is used to inhibit the expression of the corresponding gene. As the new technology, at present, it is widely used in the study of the gene function of organism and a variety of tumors. In terms of colorectal cancer, this technology is used to carry out active exploration for gene therapy re- lated with colorectal cancer, which has proved to be a new breakthrough.

关 键 词：RNAI 基因治疗 大肠癌 

分 类 号：R735.3[医药卫生—肿瘤]