7-取代喹诺酮类化合物的合成及抗癌活性  

Anticancer Activities and Synthesis of 7-Substituted Quinolone Compounds

作　　者：金国山[1] 李杰[1] 金懿[1] 苏国栋[1] 吕延文[1] 

机构地区：[1]衢州学院化学与材料工程学院,浙江衢州324000

出　　处：《化工生产与技术》2013年第4期31-33,8,共3页Chemical Production and Technology

基　　金：浙江省大学生科技创新计划项目(2012R427001);衢州学院校基金(KZY1201)

摘　　要：设计合成了10个7-取代喹诺酮类化合物,并采用噻唑兰比色实验法,研究了所合成化合物的体外抗肿瘤活性。分别对肺癌细胞A549、人白血病细胞HL-60和人子宫颈癌细胞Hela进行检测。结果表明,7-取代喹诺酮类化合物对3种癌细胞均有一定的抑制作用,尤其是对人白血病细胞HL-60的抑制效果明显,其中1种化合物的抑制活性与阳性对照相当。Designed and synthesized ten 7-substituted quinolone compounds, and studied antitumor activity in vitro of the compounds adopted thiazole blue color test method. Then detected lung carcinoma cell A549, human leukemia cells-HL 60 and human carcinoma of cervix cell Hela respectively. The results showed that 7-substituted quinolone compounds had certain inhibition for the three kinds of cancer cells, especially for human leukemia cells- HL 60, the inhibition effect was obvious, one kind of compound had fairly inhibitory activity and positive control.

关 键 词：喹诺酮类化合物 合成 抗癌活性 

分 类 号：TQ463.5[化学工程—制药化工]