低氧及其低氧诱导因子-1对动脉粥样硬化的影响  

Effect of Hypoxia and Hypoxia-inducible Factor 1 to Atherosclerosis

作　　者：张立平[1,2] 杨永健[2] 

机构地区：[1]泸州医学院研究生院,四川泸州64600 [2]成都军区总医院心内科,四川成都610083

出　　处：《心血管病学进展》2013年第5期668-671,共4页Advances in Cardiovascular Diseases

基　　金：中国人民解放军成都军区总医院科研课题(2011YG-B32)

摘　　要：动脉粥样硬化是冠状动脉、颈动脉、周围动脉等疾病极为重要的潜在病因,它可以引起很高的发病率及病死率。当组织或细胞内可利用的氧浓度降低时,低氧诱导因子-1在动脉粥样硬化中扮演着极为重要的角色,它可以促进炎症反应、内皮细胞功能障碍、泡沫细胞的形成、平滑肌细胞的增殖与迁移、血管新生、ATP的消耗等。Atherosclerosis is by far the most important underlying cause of coronary artery disease, carotid artery disease and peripheral artery disease,and is associated with high morbidity and mortality. When the consistence of oxygen in tissue or ceils is reduced, the hypoxia- inducible factor 1 may play a key role in atherosclerosis, and it may promote inflammation, dysfunctional of endothelial ceils ,formation of foam cells,proliferation and migration of smooth muscle cells, angiogenesis and ATP depletion and so on.

关 键 词：低氧 低氧诱导因子-1 动脉粥样硬化 

分 类 号：R363[医药卫生—病理学]