CD22和CD79b在慢性淋巴细胞白血病中的表达特点  

Expression of CD22 and CD79b from patients with chronic lymphocytic leukemia

作　　者：朱萍[1] 袁燕[1] 吴蓓倩[1] 牛强[1] 陈字[1] 许小平[1] 

机构地区：[1]复旦大学附属华山医院血液科,上海200040

出　　处：《临床血液学杂志（输血与检验）》2013年第5期667-669,共3页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

基　　金：国家自然科学基金项目(No:81170491)

摘　　要：目的:探讨CD22和CD79b在慢性淋巴细胞白血病(CLL)B细胞上的表达情况。方法:共收集106例初诊的CLL患者,异硫氰酸酯(FITC)标记的CD22和CD79b抗体标记细胞,流式细胞仪(FCM)检测B淋巴细胞CD22和CD79b的表达;同时以34例健康者做对照。结果:部分CLL患者B细胞表达CD22和CD79b,但是CD22和CD79b的荧光强度明显低于正常者。结论:CLL患者B细胞可以表达CD22和CD79b,但是CD22和CD79b表达特点为弱表达。Objective：To investigate the expression of CD22 and CD79b from patients with chronic lymphocytic leukemia （CLL）. Method：CD22 and CD79b expression from 106 CLL patients and 34 healthy donors were determined by flow cytometric （FCM） analysis. Result： CD22 and/or CD79b expression were detected in some CLL patients,but the expression intensity of CD22 and CD79b had decreased remarkably. Conclusion： B-cell of CLL could express CD22 and/or CD79b,but the expression of CD22 and CD79b would be weak positive.

关 键 词：慢性淋巴细胞白血病 CD22 CD79b 

分 类 号：R733.72[医药卫生—肿瘤]