早期输注不同剂量氨基酸对早产儿氮平衡的影响  

Effect of early infusion of different doses of amino acids on nitrogen balance of premature infants

作　　者：蒋曙红[1] 王金秀[1] 丁雪晶[1] 张进军[1] 张一鸣[1] 

机构地区：[1]南京医科大学附属常州市妇幼保健院新生儿科,213003

出　　处：《中国妇幼保健》2013年第30期4970-4972,共3页Maternal and Child Health Care of China

基　　金：江苏省常州市卫生局资助项目〔WZ201029〕

摘　　要：目的:评价早期输注不同剂量氨基酸对早产儿氮平衡的影响。方法:将2010年4月～2011年3月收治接受静脉营养的早产儿90例(胎龄≤32周,体重≤2 000 g)随机分成3组各30例,大剂量组于生后24 h内给予2.0 g·kg-1·d-1的氨基酸,每日递增1.0 g·kg-1·d-1,最大剂量为3.5 g·kg-1·d-1;中剂量组于生后24 h内给予1.0 g·kg-1·d-1的氨基酸,每日递增0.5 g·kg-1·d-1,最大剂量为3.5 g·kg-1·d-1;小剂量组生后24 h内给予0.5 g·kg-1·d-1的氨基酸,每日递增0.5 g·kg-1·d-1,最大剂量为3.5 g·kg-1·d-1。结果:大剂量组早产儿生后第1周每天的氮平衡均值均明显高于中、小剂量组,差异有统计学意义(P<0.05)。结论:早期输注大剂量氨基酸可改善早产儿早期氮平衡,有利于早产儿生后早期生长发育。Objective： To evaluate the effect of early infusion of different doses of amino acids on nitrogen balance of premature in- fants. Methods： Ninety premature infants （fetal age ≤ 32 weeks, birth weight ≤2 000 g） who received parenteral nutrition in the hospital from April 2010 to March 2011 were randomly divided into three groups, 30 infants in each group. The infants in large dose group were trea- ted with amino acids （2.0 g ·kg^-1·d^-1 ） within 24 hours after birth, increasing by 1. 0 g ·kg^-1·d^-1per day, and the maximal dose was 3.5 g ·kg^-1·d^-1; the infants in medium dose group were treated with amino acids （ 1.0 g ·kg^-1·d^-1） within 24 hours after birth, increasing by 0. 5 g ·kg^-1·d^-1 per day, and the maximal dose was 3.5 g ·kg^-1·d^-1 ; the infants in small dose group were treated with amino acids （0.5 g·kg^-1·d^-1） within 24 hours after birth, increasing by 0.5 g ·kg^-1·d^-1 per day, and the maximal dose was 3.5 g ·kg^-1·d^-1. Results： The daily nitrogen balance average value of the premature infants in the first week after birth in large dose group was significantly higher than that of medium dose group and small dose group, and this discrepancy had statistic significance （P 〈 0.05 ） . Conclusion： Early infusion of large dose of amino acids may improve nitrogen balance of preterm infants, and it is also conducive to the early growth and development of premature infants after their birth.

关 键 词：氨基酸 氮平衡 早产儿 静脉营养 

分 类 号：R722[医药卫生—儿科]