黄芪经侧耳菌发酵后黄芪甲苷和毛蕊异黄酮葡萄糖苷的转化  

Transformation of Astragaloside Ⅳ and Calycosin Glycoside in Radix Astragali Fermented by Pleurotus Ostreatus

作　　者：陈丽艳[1] 李月[1] 王昶[1] 曹思思[1] 王伟明[1] 

机构地区：[1]黑龙江省中医研究院,黑龙江哈尔滨150036

出　　处：《中华中医药学刊》2013年第10期2194-2197,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：黑龙江省科技计划资助项目(GA12C102)

摘　　要：目的:考察黄芪经侧耳菌发酵后黄芪甲苷和毛蕊异黄酮葡萄糖苷的变化。方法:采用薄层色谱法进行定性鉴别,高效液相色谱法进行含量测定。结果:黄芪经侧耳菌发酵后黄芪甲苷的含量降低了91%,并有新的物质产生;毛蕊异黄酮葡萄糖苷经过高温灭菌后,其含量显著降低,发酵后该成分消失。结论:黄芪在侧耳菌的作用下黄芪甲苷和毛蕊异黄酮葡萄糖苷均发生了生物转化,生成更利于人体吸收利用的物质。Objective ： To investigate the transformation of astragaloside IV and calycosin glycoside from Radix Astragali fermented by Pleurotus ostreatus. Method： TLC and HPLC methods were used to detect its components and content. Result：The content of astragaloside IV after fermentation decreased 91%, and several new components were found. The content of calycosin glycoside after sterilization at high temperature decreased obviously, and it disappeared af- ter fermented by Pleurotus ostreatus. Conclusion：Radix Astragali was fermented by Pleurotus ostreatus, and the astragaloside IV and calycosin glycoside were transformed into other compounds, which could improve activity and bioavailability.

关 键 词：黄芪 侧耳菌 发酵 黄芪甲苷 毛蕊异黄酮葡萄糖苷 

分 类 号：R284.3[医药卫生—中药学]