乳腺癌干细胞分选方法研究进展  

Advances of Breast Cancer Stem Cell Isolation

作　　者：文波[1] 刘红光[1] 

机构地区：[1]南华大学附属第一医院肿瘤外科,湖南衡阳421001

出　　处：《肿瘤药学》2013年第5期335-339,共5页Anti-Tumor Pharmacy

摘　　要：乳腺癌干细胞是来源于正常乳腺干细胞或分化乳腺细胞,具有自我更新能力、分化能力、致瘤性特征及对放疗、化疗、内分泌治疗抵抗的乳腺癌细胞。目前分离乳腺癌干细胞的方法主要有CD44+CD24-/low Lin-、乙醛脱氢酶1(ALDH1)、乳腺球、侧群细胞、DNA标记滞留细胞及改良分选方法等。本文将就近年来乳腺癌干细胞分选方法的研究进展做一综述。Breast cancer stem cells were originated from the normal mammary stern cells or the differentiated breast cancer cells, featured with the ability of self-renewal, differentiation, tumorigenicity. They were found more resistant to cancer chemo- therapy, hormone therapy and radiotherapy. At present, surface markers CD44＋CD24-/low Lin-, ALDH1 assay, mammos- pheres, side population cells, label retaining cells and improved separation methods were mainly applied to isolate breast cancer stem cells. This paper was aimed to review the advances of the methods of breast cancer stem cell isolation.

关 键 词：乳腺癌干细胞 分选方法 DNA标记 

分 类 号：R737.9[医药卫生—肿瘤]