茶多酚胶囊联合化疗治疗晚期非小细胞肺癌的临床研究  

Clinical study of Tea-polyphenol capsule combined with chemotherapy on advanced non-small cell lung cancer

作　　者：侯丽[1] 张雅月[1] 刘伟[1] 陆鸿飞[1] 倪磊[2] 董青[1] 

机构地区：[1]北京中医药大学东直门医院血液肿瘤科,北京100700 [2]北京中医药大学,北京100029

出　　处：《北京中医药》2013年第9期666-669,共4页Beijing Journal of Traditional Chinese Medicine

基　　金：首都医学科技发展基金中医药类(SF-2009-Ⅲ-13)

摘　　要：目的观察茶多酚胶囊联合化疗治疗晚期非小细胞肺癌的临床疗效。方法收集符合纳入标准的病例56例,随机不等比例分成单纯化疗组24例,采用晚期非小细胞肺癌常规化疗方案;茶多酚胶囊联合化疗组25例,参一胶囊联合化疗组7例,在化疗基础上,口服茶多酚胶囊或参一胶囊,连续用药2个周期,观察疾病控制率、中医症状疗效以及患者的生活质量。结果疾病控制率比较3组差异无统计学意义(P﹥0.05);单纯化疗组治疗前后中医症状差异无统计学意义(P﹥0.05),茶多酚胶囊联合化疗组治疗后中医症状评分下降,与治疗前比较差异有统计学意义(P<0.05);参一胶囊联合化疗组治疗后中医症状评分下降,与治疗前比较差异有统计学意义(P<0.05)。单纯化疗组患者治疗后生活质量评分下降,与治疗前比较,差异有统计学意义(P<0.01);茶多酚胶囊、参一胶囊联合化疗组治疗前后KPS比较差异无统计学意义(P>0.05)。结论茶多酚胶囊、参一胶囊联合化疗可改善肺癌患者神疲乏力、食欲不振、口干、五心烦热、失眠多梦等气阴两虚症状。在现阶段所收临床病例范围内,生活质量评分疗效由高到低依次是茶多酚胶囊联合化疗组、参一胶囊联合化疗组、单纯化疗组。Objective To observe clinical efficacy of Tea-polyphenol capsule （TPC） combined with chemotherapy on advanced non-small cell lung cancer （NSCLC）. Methods 56 cases of advanced NSCLC meeting the inclusion criteria were collected and randomly divided into 3 groupswith inequality proportion, achemotherapy group （CH group） of 24 cases which was taken withconventional chemotherapy regimen on advance NSCLC; a TPC combined with chemotherapygroup （TC group） of 25 cases and a Shenyi Capsule combined with chemotherapy group （SC group） of 7 cases, which was oral administrated with TPC or Shenyi capsule for continuous 2 cycles on the basis of chemotherapy.The disease control rate （DCR）,TCM symptom efficacy and the patient＇s quality of life （QOL） were observed. Results There was no significant difference in DCR between 3 groups （P 〉 0.05）;TCM symptom showed insignificant difference before and after the treatment in CH group（P 〉0.05）, while decreased in TC groupand SC group with significant difference （both P 〈0.05）. QOL scores of CH group were lowered obviously after the treatment （P 〈0.01）; Karnofsky （KPS） score had insignificant difference before and after the treatment in TC group and SC group （P 〉0.05）. Conclusion TPC or Shenyi capsule in combination with chemotherapy could improve the symptoms of deficiency of both qi andyin, including fatigue, loss of appetite, mouth dryness, dysphoriain chestpalms-soles, insomnia and dreaminess. Within clinical cases at present stage, the descending order of QOL scores efficacy is TC group, SC group, and CH group.

关 键 词：茶多酚胶囊 参一胶囊 晚期非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]