宁动颗粒治疗抽动-秽语综合征伴发强迫障碍的临床研究  

Clinical study of Ningdong granule on obsessive-compulsive disorder associated with Tourette＇s syndrome

作　　者：赵林[1] 李安源[1] 王志学[1] 齐芳华[1] 张峰[1] 侯广舜[1] 王媛[1] 

机构地区：[1]山东大学附属省立医院中西医结合科,济南250021

出　　处：《国际中医中药杂志》2013年第10期875-878,共4页International Journal of Traditional Chinese Medicine

基　　金：基金项目：国家自然科学基金（项目编号：81273798）;山东省自然科学基金（项目编号：zR2012HM030）;山东省科技发展计划（项目编号：2011GGB14110）;山东省中医药科技发展计划（项目编号：2013ZDZK-085）

摘　　要：目的 评价宁动颗粒治疗抽动-秽语综合征（TS）伴发强迫障碍（OCD）的临床疗效及安全性.方法 36例TS伴发OCD患者随为治疗组和对照组各18例.两组均用硫必利作为基础治疗.治疗组加用宁动颗粒,对照组加用氟西汀分散片,疗程8周.观察两组治疗前后耶鲁综合抽动严重程度量表（yale global tic severity scale,YGTSS）、耶鲁-布朗强迫量表（yale-brown obsessive compulsive scale,Y-BOCS）的评分、不良反应、血清5-羟色胺（5-HT）的含量变化.结果 治疗抽动有效率（根据YGTSS减分率）：治疗组为88.89％ （16/18）、对照组77.78％ （14/18）,两组有效率比较差异无统计学意义（P＞0.05）.治疗强迫障碍有效率（根据Y-BOCS减分率）：治疗组83.33％ （15/18）、对照组88.89％ （16/18）,两组有效率比较差异无统计学意义（P＞0.05）.两组YGTSS、Y-BOCS评分[治疗组分别为（12.72±5.20）分、（12.50±4.38）分,对照组分别为（15.50±5.39）分、（12.22±4.31）分]；与同组治疗前[治疗组分别为（27.28±8.10）分、（22.72±6.75）分,对照组分别为（29.17±7.53）分、（23.17±6.12）分]比较均降低（P＜0.01）,两组治疗后比较差异无统计学意义（P＞0.05）.治疗组血清5-HT含量为（86.05±24.26） ng/ml、对照组为（91.16±26.07） ng/ml,均较同组治疗前[治疗组（66.00±19.63） ng/ml、对照组（67.52±21.18） ng/ml]增加（P＜0.01或0.05）；两组治疗后比较,差异无统计学意义（P＞0.05）.结论 宁动颗粒联合硫必利可有效治疗TS抽动症状及伴发的强迫障碍,与氟西汀联合硫必利疗效相当.Objective To investigate the efficacy and safety of Ningdong granule on Obsessive-compulsive disorder （OCD） associated with Tourette＇s syndrome （TS）.Methods Thirty-six patients with OCD associated with TS were randomly divided into 2 groups.18 patients in the treatment group were treated with ND granule,and 18 patients in the control group were treated with fluoxetine,the initial dose of fluoxetine was 10 mg/d,and maximum dose was 60 mg/d.All of the participants with history of medication had to be medication-free for≥ 1 weeks prior to the study.The severity of tics and OCD were evaluated at baseline and at end point （8 w）,with Yale Global Tic Severity Scale （YGTSS）and Yale-Brown Obsessive Compulsive Scale （Y-BOCS）,the contents of 5-HT in serum were measured by ELISA.Side-effects were evaluated according to an adverse event chart produced by this study team.Results The effective rate of treating tics in treatment group was 88.89% （16/18）,and in control group was 77.78% （14/18）.The effective rate of treating OCD in treatment group was 83.33% （15/18）,and in control group was 88.89% （16/18）.The differences in the aspects between treatment group and control group were not significant （P〉0.05）.Compared with YGTSS scores [the treatment group was （27.28 ± 8.10）,the control group was （29.17 ± 7.53）] and Y-BOCS scores [the treatment group was （22.72 ± 6.75）,the control group was （23.17 ± 6.12）] at baseline,the scores YGTSS scores [the treatment group was （12.72±5.20）,the control group was （15.50±5.39）] and Y-BOCS scores [the treatment group was （1250± 4.38）,the control group was （12.22±4.31）] of both two groups at end point reduced significantly （P〈0.01）,but the difference between the two groups was not significant （P〉0.05）.The contents of serum 5-HT in the two groups were significantly raised after treatment [the treatment group was （86.05±24.26 vs 66.00±19.63） ng/ml,P=0.01）,the control group was （91.16±26.07 vs 6

关 键 词：抽动-秽语综合征 强迫障碍 宁动颗粒 氟西汀 硫必利 

分 类 号：R749.94[医药卫生—神经病学与精神病学]