氯谷胺的合成  

Synthesis of Loxiglumide

作　　者：孙晋瑞 刘宜辉 张治法 左玲玲 

机构地区：[1]山东省医药工业研究所山东省化学药物重点实验室,山东济南250101 [2]日照东港区医药公司,山东日照276826 [3]山东康力生药业有限公司,山东日照276826

出　　处：《食品与药品》2013年第5期317-319,共3页Food and Drug

摘　　要：目的合成急性胰腺炎用药氯谷胺。方法以谷氨酸和3,4-二氯苯甲酸为起始原料,经缩合、酐化、胺解反应合成了氯谷胺。结果及结论工艺简单,条件温和,适于大规模生产。Objective： To synthesize loxiglumide, a novel drug for acute pancreas inflammation. Methods With glutamic acid and 3,4-dichlorobenzoic acid as starting materials, loxiglumide was synthesized by condensation, anhydrization and aminolysis reactions. Results and Conclusion This route can be simple and easy controlled, and can be used in a large scale production of loxiglumide.

关 键 词：氯谷胺 谷氨酸 3 4-二氯苯甲酸 

分 类 号：R914.5[医药卫生—药物化学]