胎儿宫内生长受限发生率调查及其对胎儿-新生儿健康危害的研究  

Study on incidence rate of intrauterine growth restriction and its influence on fetal-neonatal health

作　　者：王晓凤[1] 曾军安 刘敬[1] 李占魁 唐成和[3] 孙学梅[4] 吴静[5] 王杨[6] 于亚滨[7] 

机构地区：[1]北京军区总医院附属八一儿童医院新生儿科,北京100700 [2]陕西省妇幼保健院新生儿科,陕西西安710003 [3]新乡医学院第一附属医院儿科,河南新乡453003 [4]山东省临沂市人民医院新生儿科,山东临沂276000 [5]南方医科大学何贤纪念医院新生儿科,广东广州510280 [6]安徽医科大学第一附属医院新生儿科,安徽合肥230022 [7]首都医科大学附属北京妇产医院,北京100026

出　　处：《中国儿童保健杂志》2013年第10期1020-1023,共4页Chinese Journal of Child Health Care

基　　金：国家自然科学基金资助项目(81170577)

摘　　要：目的调查我国部分省市胎儿宫内生长受限(intrauterine growth restriction,IUGR)的发生率、高危因素及其对胎儿-新生儿健康的危害。方法 1)IUGR发生率及高危因素调查:对2011年1月1日-12月31日期间,来自国内六家三级甲等医院产科出生的新生儿及孕妇资料进行分析;2)宫内生长受限对胎儿-新生儿健康危害的调查:对同期于北京军区总医院附属八一儿童医院新生儿重症监护中心住院患儿的资料进行分析。结果 1)IUGR发生率为8.77%;其中女婴9.80%,男婴为7.84%(χ2=6.285,P<0.05);早产儿中IUGR的发生率(16.43%)显著高于足月儿IUGR发生率(7.87%)(χ2=235.5,P<0.01)。2)Logistic回归分析显示妊高征、脐带异常、羊水量异常为IUGR的独立危险因素。3)IUGR患儿低血糖、窒息、缺氧缺血性脑病、消化道出血、先天畸形、红细胞增多症、肺出血、呼吸暂停、先天性心脏病、弥漫性血管内凝血等疾病的发生率明显增高,住院时间长、住院费用高(P<0.01)。结论我国IUGR发生率较高,对胎儿-新生儿健康危害大。本调查结果对我国新生儿孕产妇及围生期保健具有一定参考价值。Objective To investigate the incidence rate and high-risk factors of intrauterine growth restriction （IU- GR） and its influence on fetal-neonatal healty. Methods 1）The incidence and high-risk factors of IUGR：From Jan. 1, 2011 to Dec. 31,2011,the clinic data of maternal and newborn infants from six hospitals in China were retrospectively ana- lysed. 2）The influence of IUGR on fetal-neonatal health：the data from the NICU of Bayi Children＇s Hospital were analysed. Results 1） The incidence rate of IUGR was 8.77%. The IUGR incidence in females was 9.80% and it was 7.84% in males（P〈0.05）, and the incidence of IUGR in preterm infants （16.43 % ） was higher than that of term infants （7.87 % ）（P d0.01）. 2） Logistic analysis showed that hypertensive, abnormal amniotic fluid, and abnormality of umbilical cord were inde- pendent factors of IUGR. 3）There were significantly higher incidence of complications in IUGR infants including hypoglyce- mia,asphyxia,hypoxic ischemic encephalopathy,gastrointestinal bleeding,congenital malformation, polycythemia, pneumor- rhagia,apnea, congenital heart disease, and disseminated intravascular coagulation. Besides, IUGR prolonged their duration of hospital stayed and increased their hospitalization expenses markedly （P〈0. 05）. Conclusion The overall incidence of IUGR is as high as 8.77 % in China. IUGR has significantly adverse influence on fetal-neonatal health. These data provide some reference for maternal and perinatal health care.

关 键 词：宫内生长受限 发生率 高危因素 胎儿-新生儿健康危害 

分 类 号：R722.1[医药卫生—儿科]