氯氮平口腔崩解片与利培酮治疗精神分裂症对照研究  

Comparative study for clozapine orally disintegrating tablets and risperidone in treatment of schizophrenia

作　　者：石岩[1] 赵龙[1] 张娜[1] 安然[1] 张蕾[1] 王楠[1] 

机构地区：[1]河北省荣军医院,河北保定071000

出　　处：《中国民康医学》2013年第19期38-39,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:评价氯氮平口腔崩解片治疗精神分裂症的疗效和安全性。方法:将60例精神分裂症患者随机分为研究组(氯氮平口腔崩解片治疗)30例,对照组(利培酮治疗)30例,观察8周,于治疗前和治疗2、4、8周末采用阳性和阴性症状量表(PANSS)、副反应量表(TESS)评定疗效和安全性。结果:两组治疗8周末PANSS总分和各因子分均有不同程度下降,两组疗效差异无统计学意义(P>0.05),但研究组显效快,不良反应小。结论:氯氮平口腔崩解片对精神分裂症的疗效和利培酮相仿,但起效快且不良反应小。Objective：To explore effects and safety of clozapine orally disintegrating tablets in treatment of schizophrenia. Methods ：60 Schizophrenics were randomly divided into research group （n = 30, taking clozapine orally disintegrating tablets） and con- trol group （n= 30, taking risperidone） and observed for 8 weeks. The clinical efficacies and safety were assessed with the positive and negative syndrome scale （PANSS） and treatment emergent symptom scale （TESS） before and 2, 4 and 8 weeks after the treatment. Re- sults： 8 weeks after the treatment, the total and all factor scores of PANSS of the two groups decreased, and there was no significant difference between the two groups （ P〉0.05 ）. Moreover, research group was quick in the effects and low in the adverse reactions. Conclusions ： Clozapine orally disintegrating tablets is similar with Risperidone in the efficacy of Schizophrenia, but the side effects are less and the symptoms are improved quickly.

关 键 词：精神分裂症 氯氮平口腔崩解片 利培酮 对照研究 

分 类 号：R749.3[医药卫生—神经病学与精神病学]