富顺地区宫颈病变患者HPV感染与宫颈病变程度的关系  

Correlation between HPV infection and cervical lesions of patients with cervical diseases in Fushun area

作　　者：张元[1] 钱小华[2] 杨紫汐[1] 柴莉[1] 阮思蓓[1] 罗霞[1] 唐明希[1] 

机构地区：[1]泸州医学院病理教研室,四川泸州646000 [2]四川省富顺县人民医院病理科,四川富顺618000

出　　处：《中国医药科学》2013年第19期18-20,共3页China Medicine And Pharmacy

基　　金：泸州医学院博士启动基金(2011204);四川省泸州市科技局科技计划项目(2013-S-47)

摘　　要：目的探讨四川富顺地区不同程度宫颈病变患者人乳头瘤病毒(HPV)感染与宫颈病变的关系。方法应用基因芯片技术对富顺地区295例妇女不同程度宫颈病变样本,分为慢性宫颈炎、CINⅠ、CINⅡ、CINⅢ、乳头状瘤及宫颈癌6组,分别进行HPV基因分型检测。结果(1)HPV总感染率为58.98%,各组独立性x2及线性趋势x2检验差异均有统计学意义(P<0.05),其中,慢性炎症组为28.10%,与其余各组差异有统计学意义(P<0.05),乳头状瘤组为92.86%,与慢性炎症和CINI组差异有统计学意义(P<0.05)。(2)HR-HPV感染率为63.73%,独立x2及线性趋势x2检验差异均有统计学意义(P<0.05),其中,宫颈癌组(95.35%)与炎症(35.54%)、CINI(77.27%)及乳头状瘤组(57.14%)差异有统计学意义(P<0.05)。(3)LR-HPV感染率为21.36%,乳头状瘤组(92.86%)与其余各组差异均有统计学意义(P<0.05),宫颈癌组(27.91%)与炎症组(13.22%)差异有统计学意义(P<0.05)。结论富顺地区妇女不同程度的宫颈病变与HPV及HR-HPV感染率有关,且有随感染率升高而病变程度加重的趋势。乳头状瘤的高危因素为LR-HPV感染。Objective To explore the correlation between human papilloma virus（HPV） infection and cervical lesions of patients with varying degrees of cervical diseases in Fushun area,Sichuan province. Methods The samples from 295 women with varying degrees of cervical diseases in Fushun area were divided into 6 groups, namely chronic cervicitis,CIN I ,CIN II ,CIN III ,papilloma and cervical cancer by using gene array technology,and were done HPV genotyping test respectively. Results （1）The total infection rate of HPV was 58.98%,the independent chi-square test and trend test both showed that the difference was statistically significant among the groups（P 〈 0.05）.Of which the HPV infection rate in chronic cervicitis group was 28.10%, and the difference was statistically significant between chronic cervicitis group and other groups（P 〈 0.05）;while that in papilloma group was 92.86%,and the difference was statistically significant between papilloma group and chronic cervicitis group or CIN I group（P 〈 0.05）.（2）The infection rate of HR-HPV was 63.73%, the independent chi-square test and trend test both showed that the difference was statistically significant among the groups（P 〈 0.05）.There were significant differences in the infection rate of HR- HPV between cervical cancer group（95.35%） and chronic cervicitis group（35.54%） or CIN I group（77.27%） or papilloma group（57.14%）, P 〈 0.05.（3）The infection rate of LR-HPV was 21.36%,and there were significant differences in the infection rate of LR-HPV between papilloma group（92.86%） and other groups（P 〈 0.05） and between cervical cancer group（27.91%） and chronic cervicitis group（13.22%）,P 〈 0.05. Conclusion HPV or HR-HPV infection rate is positively associated with varying degrees of cervical pathological changes in women from Fushun area,and cervical lesions aggravates with rising infection rate.The LR-HPV infection is the risk factor for the patients with papilloma.

关 键 词：四川富顺地区 人乳头瘤病毒 基因芯片技术 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]