肾盂癌中抑癌基因p16的表达意义  

Expression significance of p16 gene in renal pelvis carcinoma

作　　者：袁建林[1] 种铁[2] 王禾[1] 陈宝琦[1] 秦荣良[1] 武国军[1] 于茂生[1] 

机构地区：[1]第四军医大学西京医院泌尿外科,陕西西安710033 [2]西安交通大学第二医院泌尿外科

出　　处：《第四军医大学学报》2000年第12期1465-1467,共3页Journal of the Fourth Military Medical University

基　　金：陕西省自然科学基金资助项目! (2 0 0 0 SM40 )

摘　　要：目的　研究抑癌基因 p16与肾盂癌病理分级、临床分期及预后的关系 .方法　应用免疫组织化学对 40例肾盂癌标本中抑癌基因 p16的表达进行检测 .结果　 40例肾盂癌组织中 p16基因表达的阳性率为 5 2 .5 % ,其阳性率随肾盂癌病理分级、临床分期的上升而降低 ,p16表达阳性者 3a生存率明显高于阴性者 .结论　 p16基因在抑制肾盂癌的发生、发展中起重要作用 ,其检测可用于评估肾盂癌的恶性度和预后 .AIM To elucidate the correlation between p16 gene and tumor grade'stage、prognosis of renal pelvis carcinoma. METHODS Expression of p16 in 40 cases of renal pelvis carcinoma was detected by immunohistochemistry. RESULTS Total positive rate of p16 gene was 52.5%;the worse the grading and staging,the lower the presence of p16;There was a significant difference between p16 positive and negative cases in 3-year survival rate. CONCLUSION p16 gene plays an important role in suppressing the development of renal pelvis carcinoma and could be used as a predictor of malignant potentiality and prognosis.

关 键 词：肾盂癌 抑癌基因 P16基因 免疫组织化学 

分 类 号：R737.11[医药卫生—肿瘤]