脉血康联合阿司匹林预处理对大鼠脑缺血-再灌注损伤的影响  

Effects of Maixuekang and aspirin pretreating on cerebral ischemia-reperfusion injury in rats

作　　者：徐德友 印卫兵 沈华超 朱金 沈丽华 王蔚 徐连宝 王华梅 丁新生 

机构地区：[1]南京医科大学第一附属医院神经内科,江苏省210029

出　　处：《江苏医药》2013年第19期2244-2246,共3页Jiangsu Medical Journal

摘　　要：目的探讨脉血康联合阿司匹林预处理对大鼠脑缺血-再灌注(I-R)损伤的防治作用。方法 40只SD大鼠随机均分为五组,A、B、C、D组建立脑I-R损伤模型;E组为假手术对照。A、B、C组分别用阿司匹林10mg·kg-1·d-1、脉血康1.0g·kg-1·d-1和两者联合给药实施预处理;预处理药物均溶于4ml生理盐水中,每日灌胃1次,连续14d。观察大鼠神经功能缺损评分和脑梗死体积,检测大鼠凝血功能及血液流变学指标。结果与D组比较,A、B、C组神经功能缺损评分及脑梗死体积均有显著改善,C组效果更好(P<0.05或P<0.01)。A、B、C组血液流变学和凝血功能检测值均明显优于D组,C组优于A、B组(P<0.05或P<0.01)。结论脉血康或阿司匹林预处理对大鼠脑I-R损伤有一定的保护作用,联合给药效果更好。Objective To investigate the effects of Maixuekang and aspirin pretreating on cerebral ischemia-reperfusion （I-R） injury in rats. Methods Forty male SD rats were equally randomized into five groups. The cerebral I-R injury models were established in groups of A, B,C and D. Group E was taken as sham-operation control. The rats in groups of A, B and C were pretreated with aspirin 10 mg·kg^-1·d^-1, Maixuekang 1.0 g·kg^-1·d^-1 and combined use of both drugs, respectively. The drugs pretreated were dissolved in normal saline 4 ml and given by gastric garage once a day for 14 days. Neurological function deficits were scored and cerebral infarct volumes were calculated by TTC stain. Blood theology and blood coagulation were examined as well. Results Compared with group D, the scores of neurological function deficit and cerebral infarct volumes were significantly improved in groups of A,B and C,which were better in group C than those in groups of A and B（P〈0. 05 or P〈0. 01）. So did the results of blood rheology and blood coagulation（P〈0. 05 or P〈0.01）. Conclusion Pretreated with Maixuekang or aspirin, especially combined use of both drugs, is effective in attenuating the cerebral I-R injury in rats.

关 键 词：脉血康 阿司匹林 脑缺血-再灌注损伤 

分 类 号：R743[医药卫生—神经病学与精神病学]