OPN和Msx2在鼻内翻性乳头状瘤中的表达及意义  

Expression and significance of osteopontin and muscle segment homeobox gene Msx2in sinonasal inverted papilloma

作　　者：吴延平[1] 崔顺九[2] 吴琼芳[1] 马喆[1] 袁伟[1] 

机构地区：[1]邯郸市第三医院(眼科医院)耳鼻咽喉科,河北邯郸056000 [2]首都医科大学附属北京同仁医院耳鼻咽喉科

出　　处：《临床耳鼻咽喉头颈外科杂志》2013年第20期1114-1117,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨骨桥蛋白(OPN)和肌节同源盒基因同系物2(Msx2)在鼻内翻性乳头状瘤(SNIP)组织中的表达和意义,及两因子在SNIP恶变发生、发展过程中的关系。方法:采用免疫组织化学SP法检测OPN和Msx2在32例SNIP、30例鼻息肉(INP)和30例恶变SNIP蜡块组织中的表达情况,其中SNIP组又根据病理形态分为轻度不典型增生组、中度不典型增生组和重度不典型增生组。所有数据均采用SPSS13.0软件包进行统计学分析。结果:OPN和Msx2在恶变SNIP组中的阳性表达率均为100%(30/30),均显著高于SNIP组和INP组中的阳性表达率,且两两比较差异均有统计学意义(P<0.05)。OPN和Msx2在SNIP的三个病理形态分组间的阳性表达比较:轻度不典型增生组与重度不典型增生组比较差异具有统计学意义(P<0.05),而轻度不典型增生组与中度不典型增生组比较、中度不典型增生组与重度不典型增生组比较差异均无统计学意义(P>0.05)。OPN和Msx2在SNIP中的表达呈正相关(P<0.01)。结论:OPN和Msx2在SNIP恶变的发生、发展过程中起重要作用,有可能成为SNIP基因治疗的靶点。Objective：To investigate the expression level and significance of osteopontin（（）PN） and muscle segment homeobox2（Msx2） in sinonasal inverted papilloma（SNiP）,and the relationship with the process of SNIP malignant transfomation. Method： Immunohistoehenfical method was used to detect the expression of osteopontin and Msx2 in 32 cases of sinonasal inverted papilloma（SNIP）, 30 cases of inflammatory nasal polyp paraffin tissue （INP） and 30 cases of sinonasal inverted papilloma with carcinoma. According to the pathology results SNIP were divided into mild dysplasia,moderate dysplasia, severe dysplasia. All the datas were analyzed by SPSS13.0. Result：The positive expression of OPN and Msx2 in the SNIP with carcinoma were all 100%（30/30）, were significantly higher than the SNIP and INP, and the pairwise comparisons were all statistically significant（P〈0.05）. The expression of OPN and Msx2 in the SNIP were divided according to pathological. There was significant difference between mild dysplasia and severe dysplasia group（P〈0.05）, while there were not significant difference be tween light degree of dysplasia and moderate dysplasia group, moderate dysplasia and severe dysplasia group. And the expression of OPN and Msx2 was positively correlated in SNIP（P〈0.01）. Conclusion： OPN and Msx2 may play an important role in the pathway of progression of SNiP,which may be identified as the new therapeutic tar gets.

关 键 词：乳头状瘤 内翻 骨桥蛋白 肌节同源盒基因同系物2 免疫组织化学 

分 类 号：R739.62[医药卫生—肿瘤]