雌激素受体在胃癌细胞的表达和意义  

Expression and significance of estrogen receptor in gastric carcinomas

作　　者：张小雨[1] 吴小翎[1] 

机构地区：[1]重庆医科大学第二临床学院消化内科,重庆400010

出　　处：《重庆医科大学学报》2000年第4期357-358,共2页Journal of Chongqing Medical University

摘　　要：目的 　检测雌激素受体（ER）在胃癌的表达及其与胃癌生物学行为的关系。方法　 应用免疫组化S－P法。结果　ER在慢性浅表性胃炎、异型增生中表达均为阴性，在胃癌阳性率为40%，三组比较有显著性差异（Ｐ<0.05）。ER在进展期胃癌的阳性率显著高于早期胃癌（Ｐ<0.05）；胃癌有淋巴结转移组的阳性率显著高于无淋巴结转移组（Ｐ<0.05）。ER的表达在分化不良型胃癌高于分化型胃癌，但无统计学意义（Ｐ>0.05）。 结论　ER 可作为胃癌的生物学标志， ER阳性的胃癌可能具有更强的浸润与转移能力。：Objective To study the relationship of expression ER with gastric mucosal carcinogenesis and behavior of gastric carcinoma. Methods S-P immunohistochemistry method. Results The study showed expression of ER was negative in chronic superficial gastritis and dysplasia.The positive rate of ER in gastric carcinomas was 40% . Statistically , the positive rates of ER in advanced gastric carcinomas were significantly higher than those in early gastric carcinomas（Ｐ<0.05）. The positive rates of ER in the group with lymph node metastasis were significantly higher than those in the group without lymph node metastasis (Ｐ<0.05). Conclusion ER might play important roles in the process of carcinogenesis of gastric mucosa ，and be used as useful markers for the assessment of biological behavior of gastric carcinoma .

关 键 词：雌激素受体 癌前病变 胃肿瘤 免疫组化 

分 类 号：R735.202[医药卫生—肿瘤]